ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Bisphenol A
Physicochemical properties
Chemical name NLBisfenol A
Chemical name ENBisphenol A
CAS no80-05-7
UN-
Chemical formulaC15 H16 O2
Molecular weight228,29
Boiling point220蚓 at 4 mm Hg
Melting point150-155蚓
Density1,2
Vapour pressure0,2 mm Hg at 170蚓
Solubility<1 mg/l at 21,5蚓
LogKow-
PhaseSolid
NotesDiphenylalkane
Persistenceno
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
amphibiansuspected no endocrine effect
No inhibition of progesterone-induced oocyte maturation
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amphibianEffect on estrogen
Inhibition of [3H]estradiol binding to ER
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amphibianEffect on estrogen
Induction of VTG mRNA
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amphibianEffect on estrogen
Increased number of female phenotypes
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crustaceansuspected endocrine effect
Stimulated ovarian maturation, measured as an increased egg production rate
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fishEffect on estrogen
Induction of vitellogenesis
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fishEffect on estrogen
100% female sex ratio
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fishEffect on estrogen
Induction of testis-ova
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fishEffect on estrogen
Induction of vitelllogenesis
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fishEffect on estrogen
70.2-106 痢/l: increased plasma VTG concentrations (not significant)
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fishEffect on estrogen
556 痢/l: significant induction of vitellogenesis
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fishEffect on estrogen
Significantly decreased number of eggs and hatchings
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fishEffect on estrogen
Approximately 300-fold increases in plasma VTG levels
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fishsuspected no endocrine effect
Increased HSI
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mammalianEffect on estrogen
RBA compared to radiolabeled 17-beta-estradiol (%): 0.01
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mammalianEffect on estrogen
RBA compared to radiolabeled 17-beta-estradiol (%): 0.01
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mammalianEffect on estrogen
Inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Potency relative to 17-beta-estradiol: 0.0001
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mammaliansuspected no endocrine effect
No significant displacement of T4 from transthyretin
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mammalianEffect on estrogen
Induction of estrogen-mediated gene transcription
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mammalianEffect on estrogen
Induction of estrogen-mediated gene transcription
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mammalianEffect on estrogen
1 g/kg: increased peroxidase activity
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mammaliansuspected no endocrine effect
10 痢 - 100 mg: no evidence for estrogenic activity
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mammalianEffect on estrogen
Inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Relative binding affinity: 0.00013
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mammalianEffect on estrogen
Inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Relative binding affinity: 0.000013
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
Stimulation of transcriptional activity of ER
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mammalianEffect on estrogen
Increased uterus weight
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mammalianEffect on estrogen
Increased uterus weight
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mammalianEffect on estrogen
600-800 mg/kg: premature vaginal opening
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mammalianEffect on estrogen
Calculated log RBA: -1.14
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mammalianEffect on estrogen
Calculated log RBA: -0.18
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mammalianEffect on estrogen
Predicted log RBA: -1.16
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mammalianEffect on estrogen
Predicted log RBA: -0.52
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mammaliansuspected endocrine effect
Reduction in efferent duct epithelial cell height
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mammalianEffect on estrogen
Inhibition of fluorescent ligand ES1 binding to ER
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mammalianEffect on estrogen
RBA compared to estradiol: 0.04%
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mammalianEffect on estrogen
Induction of proliferation (full agonist)
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mammalianEffect on estrogen
Relative potency to 17-beta-estradiol: 0.01%
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mammalianEffect on estrogen
Increased PR concentration
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mammalianEffect on estrogen
Induction of 17-beta-estradiol-mediated gene expression
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mammalianEffect on estrogen
Relative potency to 17-beta-estradiol: 0.1%
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mammalianEffect on estrogen
RBA compared to 17-beta-estradiol: 0.056%
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
Induction of estrogen-dependent transcription
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mammalianEffect on estrogen
Dose dependent tumor development
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mammalianEffect on estrogen
Induction of ERalpha-mediated transcription
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mammalianEffect on estrogen
1-100 nM in combination with 10 nM 17-beta-estradiol: agonist
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mammalianEffect on estrogen
1 然 in combination with 10 nM 17-beta-estradiol: antagonist
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mammalianEffect on estrogen
Induction of ERalpha-mediated transcription
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mammalianEffect on estrogen
Combination with 10 nM 17-beta-estradiol: agonist
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mammalianEffect on estrogen
Induction of ERalpha-mediated transcription
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mammaliansuspected no endocrine effect
No induction of PXR-mediated transcription
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mammaliansuspected endocrine effect
Increased CYP3A1 mRNA expression
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mammalianEffect on estrogen
Activation of ERalpha
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mammalianEffect on estrogen
Potency compared to 17-beta-estradiol: 0.038
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mammalianEffect on estrogen
Activation of ERalpha
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mammalianEffect on estrogen
Increased peroxidase activity (estrogen-responsive)
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mammalianEffect on estrogen
Increased PR levels (estrogen-responsive)
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mammaliansuspected no endocrine effect
No effect on reproductice organs weights
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mammaliansuspected no endocrine effect
No effect on reproductice organs weights
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mammaliansuspected no endocrine effect
No effect on reproductice organs weights
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mammaliansuspected endocrine effect
Altered expression and activities of male-specific cytochrome P450 isoforms
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mammalianEffect on estrogen
Dose-dependent uterotrophic activity
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mammalianEffect on estrogen
128-250 mg/kg: dose-dependent pituitary gland hypertrophy
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mammalianEffect on pituitary hormone
128-250 mg/kg: dose-dependent hyperprolactinaemia
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mammalianEffect on estrogen
Increased risk for breast cancer (significantly dependent on duration of exposure)
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mammalianEffect on estrogen
Increased mean uterus wet weight (EC50 = 0.72 mg/day)
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mammalianEffect on estrogen
2 mg/day: increased luminal epithelial height and thickness of stromal and myometrial layers
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mammaliansuspected no endocrine effect
Female offspring: no apparent adverse effects on pubertal development and reproductive functions
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mammaliansuspected no endocrine effect
Male offspring: no significant effects on reproductive organ weights and micromorphology
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
Additivity in combination with 4-tert-octylphenol (0.05 然) and technical 4-nonylphenol (0.05 然)
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mammalianEffect on estrogen
Partial additivity in combination with benzyl-n-butylphtalate (2 然) and 4-hydroxybiphenyl (1 然)
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mammalianEffect on estrogen
Dose-dependent induction of cell proliferation (RPE > 70%)
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mammalianEffect on estrogen
EEQ: 58-70 ng/l
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mammalianEffect on estrogen
Quantified phenolic compounds: 0.72-0.83% of total estrogenic activity
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mammalianEffect on estrogen
Dose-dependent induction of cell proliferation (RPE: 40%)
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mammalianEffect on estrogen
EEQ: 6 ng/l
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mammalianEffect on estrogen
Quantified phenolic compounds: 1.4-4.3% of total estrogenic activity
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
RPE: 97.4%
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mammaliansuspected endocrine effect
Sex-specific effects on nonsocial behavior
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mammaliansuspected endocrine effect
Sex-specific effects on nonsocial behavior
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mammaliansuspected endocrine effect
Decreased plasma free testosterone levels
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mammaliansuspected endocrine effect
Multinucleated giant cells in the seminiferous tubules of the testis
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mammaliansuspected endocrine effect
IC50 for [3H]testosterone displacement from SHBG: 51 然
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mammaliansuspected endocrine effect
IC50 for [3H]17-beta-estradiol displacement from SHBG: 13.6 然
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mammaliansuspected endocrine effect
100 然: 30% increase in non-SHBG-bound testosterone
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mammaliansuspected endocrine effect
100 然: 16% increase in non-SHBG-bound 17-beta-estradiol
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mammalianEffect on estrogen
RTA for ERalpha compared to radiolabeled 17-beta-estradiol (%): 50
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mammalianEffect on estrogen
RTA for ERbeta compared to radiolabeled 17-beta-estradiol (%): 41
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yeastEffect on estrogen
Induction of hER-mediated transcription
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yeastEffect on estrogen
Relative potency to 17-beta-estradiol: 0.0001
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yeastEffect on anti-androgen
Inhibition of DHT activity (dose-dependent)
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yeastEffect on estrogen
Induction of ER-mediated gene expression
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yeastEffect on estrogen
Induction of ER-mediated gene expression
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yeastEffect on estrogen
Induction of ER-mediated gene expression
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yeastEffect on estrogen
Induction of hER dimerization (101.2% of maximal estradiol response)
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yeastEffect on estrogen
Induction of hER-dependent gene transcription (62.4% of maximal estradiol response)
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yeastEffect on estrogen
Inhibition of tritiated estradiol binding to ER
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yeastsuspected no endocrine effect
No induction of PXR-mediated transcription
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yeastEffect on estrogen
Induction of ER-mediated transcription
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.