ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
DDT
Physicochemical properties
Chemical name NLDDT
Chemical name ENDDT
CAS no50-29-3
UN-
Chemical formulaC14H9Cl5
Molecular weight354,49
Boiling point260°C
Melting point108°C
Density-
Vapour pressure1,9E-7 mm Hg at 20°C
Solubility3,1-3,4 µg/l
LogKow6,19
PhaseSolid
NotesTechnical DDT p,p'-isomer predominant component (up to 30% o,p'-DDT)
Persistenceyes
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
amphibianEffect on anti-estrogen
Females: decreased müllerian duct epithelial area
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amphibianEffect on anti-estrogen
Females: inhibition of 17-beta-estradiol action
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amphibiansuspected no endocrine effect
Males: no significant effect on müllerian duct
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amphibiansuspected no endocrine effect
Both sexes: no effect on wolffian ducts
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amphibiansuspected no endocrine effect
Males: no significant effect on müllerian duct
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amphibiansuspected no endocrine effect
Both sexes: no effect on wolffian ducts
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birdEffect on estrogen
Altered sex ratio in favour of females
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crustaceansuspected endocrine effect
Slightly increased male to female sex ratio (not significant)
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mammaliansuspected endocrine effect
Decreased plasma testosterone concentrations
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mammalianEffect on estrogen
Proliferation of cells; relative potency to estradiol: 0.0001%
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mammaliansuspected endocrine effect
Decreased ovulation rate
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mammalianEffect on estrogen
Induction of estrogen-mediated transcription
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mammaliansuspected no endocrine effect
No induction of PXR-mediated transcription
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mammaliansuspected no endocrine effect
No apparent association between serum concentrations and the risk of breast cancer
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yeastsuspected no endocrine effect
No induction of PXR-mediated transcription
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.