| Organism group |
Effect | |
| mammalian | suspected endocrine effect
Increased pituitary wet weight (hyperaemia and hypertrophy) |
Show study |
| mammalian | suspected endocrine effect
Reduced activity of steroid metabolizing enzymes |
Show study |
| mammalian | suspected endocrine effect
Male pups: decreased number of androgen-specific binding sites in prostate |
Show study |
| mammalian | suspected no endocrine effect
Male pups: no effects pituitary metabolism |
Show study |
| mammalian | suspected endocrine effect
Female pups: increased 5-alpha-steroid reductase activity |
Show study |
| mammalian | suspected no endocrine effect
Female pups: no effects on pituitary androgen metabolism |
Show study |
| mammalian | suspected endocrine effect
Male pups: decreased 3-alpha-hydroxysteroid dehydrogenase and 5-alpha-steroid reductase |
Show study |
| mammalian | suspected endocrine effect
Hyperplasia of mammary gland and prostate |
Show study |
| mammalian | suspected endocrine effect
Mammary fibroadenomas and adenocarcinomas |
Show study |
| mammalian | Effect on estrogen
75 mg/kg: disrupted 4-day ovarian cycle |
Show study |
| mammalian | Effect on estrogen
150 mg/kg: repetitive pseudopregnancies |
Show study |
| mammalian | suspected no endocrine effect
300 mg/kg: regression of ovaries and anestrous condition |
Show study |
| mammalian | Effect on estrogen
75 mg/kg: disrupted 4-day ovarian cycle |
Show study |
| mammalian | Effect on estrogen
150 mg/kg: repetitive pseudopregnancies |
Show study |
| mammalian | Effect on estrogen
300 mg/kg: repetitive pseudopregnancies |
Show study |
| mammalian | suspected endocrine effect
Prolongation of estrous cycle: increase of days in estrus, decrease of days in diestrus |
Show study |
| mammalian | suspected endocrine effect
Cornification of vaginal epithelium |
Show study |
| mammalian | Effect on anti-estrogen
Decrease in circulating estradiol levels |
Show study |
| mammalian | suspected endocrine effect
Decrease of days in estrus, increase of days in diestrus |
Show study |
| mammalian | Effect on anti-estrogen
Decrease in circulating estradiol levels |
Show study |
| mammalian | suspected no endocrine effect
No effect on [3H] 5-alpha-DHT binding to SHBG |
Show study |
| mammalian | suspected no endocrine effect
No significant inhibition of estradiol binding to ER |
Show study |
| mammalian | Effect on androgen
40-50% decrease in [3H]5-alpha-DHT binding to ABP |
Show study |
| mammalian | Effect on androgen
30-40% inhibition in [3H]5-alpha-DHT binding to AR |
Show study |
| mammalian | suspected no endocrine effect
No induction of ER-mediated responses |
Show study |
| mammalian | suspected no endocrine effect
No induction of ER-mediated responses |
Show study |
| mammalian | suspected endocrine effect
Increased incidence in breastcancer |
Show study |
| mammalian | Effect on catecholamine
Dose-dependent inhibition of TH-mediated dopamine synthesis |
Show study |
| mammalian | Effect on catecholamine
100-200 µM: dose-dependent inhibition of DbH-mediated norepinephrine synthesis |
Show study |
| mammalian | suspected no endocrine effect
200 µM: reduced cell viability at 24 hours of exposure |
Show study |
| reptile | suspected no endocrine effect
No sex reversal |
Show study |
| reptile | suspected no endocrine effect
No effects on hatchling plasma hormone concentrations or gonadal aromatase activity |
Show study |
| reptile | suspected no endocrine effect
No effects on CAF hormone concentrations |
Show study |
| reptile | Effect on anti-estrogen
Inhibition of [3H]17-beta-estradiol binding to ER |
Show study |
| reptile | Effect on anti-estrogen
35% inhibition of R5020 binding to PR |
Show study |
| yeast | suspected no endocrine effect
No significant induction of hER-mediated transactivation |
Show study |
| yeast | suspected no endocrine effect
No hER binding |
Show study |
| yeast | suspected no endocrine effect
No estrogenic activity |
Show study |
| yeast | suspected no endocrine effect
No ER-mediated growth |
Show study |
