ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Simazine
Physicochemical properties
Chemical name NLSimazine
Chemical name ENSimazine
CAS no122-34-9
UN-
Chemical formulaC7H12ClN5
Molecular weight201,7
Boiling point-
Melting point225-227°C
Density1,302 at 20°C
Vapour pressure8,1E-7 Pa at 20°C
Solubility5 mg/l at 20°C
LogKow1,95
PhaseSolid
Notes
Persistenceno
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
mammaliansuspected endocrine effect
Prolongation of estrous cycle: increase of days in estrus, decrease of days in diestrus		 Show study
mammaliansuspected endocrine effect
Cornification of vaginal epithelium		 Show study
mammalianEffect on anti-estrogen
Decrease in circulating estradiol levels		 Show study
mammaliansuspected endocrine effect
Decrease of days in estrus, increase of days in diestrus		 Show study
mammalianEffect on anti-estrogen
Decrease in circulating estradiol levels		 Show study
mammaliansuspected endocrine effect
Increased incidence in breastcancer		 Show study
mammalianEffect on catecholamine
Dose-dependent inhibition of TH-mediated dopamine synthesis		 Show study
mammalianEffect on catecholamine
100-200 µM: dose-dependent inhibition of DbH-mediated norepinephrine synthesis		 Show study
mammaliansuspected no endocrine effect
No induction of ER-mediated responses		 Show study
mammaliansuspected no endocrine effect
No induction of ER-mediated responses		 Show study
yeastsuspected no endocrine effect
No ER-mediated growth		 Show study
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.