ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Cadmium
Physicochemical properties
Chemical name NLCadmium
Chemical name ENCadmium
CAS no7440-43-9
UN-
Chemical formulaCd
Molecular weight112,41
Boiling point765C
Melting point320,9C
Density-
Vapour pressure-
Solubilityinsoluble
LogKow-
PhaseSolid
Notes
Persistenceyes
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
fishEffect on corticosteroid
10 g/l: increased plasma cortisol levels
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fishsuspected endocrine effect
25 g/l: decreased plasma calcium concentrations
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fishEffect on corticosteroid
Increased plasma cortisol levels
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fishEffect on corticosteroid
2 days: increased plasma cortisol levels
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fishEffect on corticosteroid
7 and 14 days: decrease of plasma cortisol concentrations to basal levels
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fishEffect on corticosteroid
30 days: increased plasma cortisol levels
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fishEffect on corticosteroid
30 days: increased in vitro ACTH-induced cortisol secretion
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mammalianEffect on neurohormone
Decreased 5-HT levels in hypothalamus
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mammalianEffect on neurohormone
Increased 5-HT turnover in anterior hypothalamus and median eminence
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mammalianEffect on androgen
Increased plasma testosterone levels
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mammaliansuspected endocrine effect
Age dependent accumulation of Cd in hypothalamus and testes
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mammalianEffect on catecholamine
Increased NE levels in hypothalamus
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mammalianEffect on catecholamine
Decreased NE levels in median eminence
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mammalianEffect on gonadotropin
Decreased plasma FSH levels
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mammalianEffect on neurohormone
Decreased 5-HT levels in hypothalamus
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mammalianEffect on neurohormone
Increased 5-HT turnover in anterior and posterior hypothalamus
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mammalianEffect on anti-androgen
Decreased plasma testosterone levels
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mammaliansuspected endocrine effect
Age dependent accumulation of Cd in hypothalamus, pituitary and testes
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mammalianEffect on catecholamine
Decreased NE levels in anterior and mediobasel hypothalamus and median eminence
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mammaliansuspected endocrine effect
Abnormal sperm morphology and decreased sperm motility
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mammaliansuspected endocrine effect
Increased serum LH and testosterone levels
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mammaliansuspected endocrine effect
Decreased serum prolactin levels
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mammalianEffect on thyroid hormone
Decreased serum free T4 levels
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mammalianEffect on thyroid releasing hormone
Increased serum TSH levels
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mammalianEffect on gonadotropin
Decreased pulse frequency and mean halfilife of LH
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mammalianEffect on gonadotropin
Decreased mean serum levels and pulse duration of LH
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mammalianEffect on gonadotropin
Increased LH pulse frequency
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yeastEffect on anti-estrogen
Inhibition of estradiol-mediated transcriptional activity
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yeastEffect on anti-estrogen
Inhibition of estradiol-mediated transcriptional activity
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yeastEffect on anti-estrogen
Inhibition of ER DNA-binding activity
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yeastEffect on anti-estrogen
Inhibition of ER DNA-binding activity
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.