ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Tributyltin (Tributylstannane)
Physicochemical properties
Chemical name NLTributyltin (Tributylstannaan)
Chemical name ENTributyltin (Tributylstannane)
CAS no688-73-3
UN-
Chemical formulaC12H28Sn
Molecular weight291,01
Boiling point-
Melting point-
Density-
Vapour pressure-
Solubility-
LogKow-
Phase-
Notes
Persistenceyes
Degradation
Accumulationyes
Endocrien effect studies
Organism group Effect 
crustaceansuspected no endocrine effect
No effect on reproduction and sex ratio
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echinodermsuspected endocrine effect
Females: smaller mature oocytes and thinner gonadal epithelium
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echinodermsuspected no endocrine effect
Males: not significant decrease in gonadal epithelium thickness
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molluscsuspected endocrine effect
Highly significant positive correlation between female TBT body burden and intersex index (0-12 mg/kg dry weight)
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molluscsuspected endocrine effect
Highly significant positive correlation between sediment TBT concentration and intersex index in females (100-10000 µg/kg dry weight)
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molluscsuspected endocrine effect
Highly significant positive correlation between sediment TBT concentration and female prostate length (100-10000 µg/kg dry weight)
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molluscsuspected endocrine effect
Highly significant positive correlation between sediment TBT concentration and % of sterile females (100-10000 µg/kg dry weight)
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molluscsuspected endocrine effect
Highly significant negative correlation between male TBT body burden and reduction of male penial glands
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molluscsuspected endocrine effect
11 mg/kg dry weight in males: 75% reduction of male penial glands
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molluscsuspected no endocrine effect
No increase in intersex index
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molluscsuspected endocrine effect
Females: concentration dependent occurrence of intersex stages
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molluscsuspected endocrine effect
Males: concentration dependent reduction of male penial glands
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molluscsuspected endocrine effect
Increased incidence of imposex
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molluscEffect on androgen
Correlation between the incidence of imposex and TBT-contamination
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molluscEffect on androgen
Correlation between the incidence of intersex and TBT-contamination
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molluscEffect on androgen
Correlation between the incidence of intersex and TBT-contamination
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molluscEffect on androgen
Correlation between the incidence of imposex and TBT-contamination
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molluscEffect on androgen
Correlation between shell thickness and TBT-contamination
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molluscEffect on androgen
32% increase in testosterone titres
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molluscEffect on androgen
52, 71 and 81% decrease in estradiol titres after 1, 3 and 5 weeks, respectively
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molluscEffect on androgen
Increased inicidence of imposex
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molluscEffect on androgen
Development of imposex
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molluscsuspected endocrine effect
Increased testosterone levels
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molluscsuspected endocrine effect
Decreased aromatization of testosterone to estrone and estradiol
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molluscsuspected endocrine effect
Reduction in the total metabolism of testosterone
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molluscsuspected endocrine effect
Altered testosterone metabolite profile
Show study
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.