ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Methoxychlor
Physicochemical properties
Chemical name NLMethoxychlor
Chemical name ENMethoxychlor
CAS no72-43-5
UN-
Chemical formulaC16H15Cl3O2
Molecular weight345,66
Boiling point-
Melting point86-88C
Density1,41 at 25C
Vapour pressure1E-3 Pa at 22C
Solubility0,04 mg/l at 24C
LogKow4,30
PhaseSolid
Notes
Persistenceno
Degradation
Accumulationyes
Endocrien effect studies
Organism group Effect 
amphibianEffect on progestogen
Inhibition of progesterone-induced oocyte maturation
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crustaceansuspected endocrine effect
Slightly increased male to female sex ratio (not significant)
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fishEffect on estrogen
Inhibition of radiolabeled estradiol binding to ER; relative potency (%) to estradiol: 0.015
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fishEffect on estrogen
Inhibition of radiolabeled estradiol binding to ER
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fishEffect on estrogen
Relative potency to 17-beta-estradiol: 0.00002
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fishEffect on estrogen
Slightly increased serum vitellogenin
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fishsuspected no endocrine effect
No significant binding to AR in brain and ovaries
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fishsuspected endocrine effect
RBA to testosterone at 50%: 0.008%
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fishsuspected no endocrine effect
No binding to AR in brain, testes and ovaries
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fishsuspected no endocrine effect
No significant induction of vitellogenesis
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fishsuspected no endocrine effect
No effect on sex ratio
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fishsuspected no endocrine effect
No depreciation in reproductive capability
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mammalianEffect on estrogen
Increased estrogen responsive transcription of LF and G6PD mRNA transcription
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mammalianEffect on estrogen
10% reduction of tritiated 17-beta-estradiol binding to ER
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mammaliansuspected no endocrine effect
No effect on tritiated 5-alpha-DHT binding on AR
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mammalianEffect on androgen
40-50% decrease in tritiated 5-alpha-DHT binding to ABP
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mammaliansuspected no endocrine effect
No effect on tritiated 5-alpha-DHT binding to SHBG
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mammalianEffect on estrogen
0.5-500 mg/kg: increased relative uterus weight
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mammalianEffect on estrogen
100-500 mg/kg: increased peroxidase activity
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mammalianEffect on estrogen
500 mg/kg: induction of cell proliferation
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mammalianEffect on estrogen
Inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Relative binding affinity: 0.0000031
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
Stimulation of transcriptional activity of ER
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mammalianEffect on estrogen
Calculated log RBA: -1.91
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mammalianEffect on estrogen
Calculated log RBA: -0.68
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mammalianEffect on estrogen
Predicted log RBA: -2.19
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mammalianEffect on estrogen
Predicted log RBA: -1.08
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mammalianEffect on estrogen
Alteration of estrogen-mediated gene expression
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mammalianEffect on estrogen
Inhibition of fluorescent ligand ES1 binding to ER
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mammalianEffect on estrogen
RBA compared to estradiol: 0.007-0.02%
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mammalianEffect on estrogen
Inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Potency relative to 17-beta-estradiol: 0.00001
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mammalianEffect on estrogen
Induction of cell proliferation
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mammalianEffect on estrogen
Induction of estrogen-dependent transcription
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mammalianEffect on anti-androgen
Inhibition of DHT-induced activity (antagonist)
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mammaliansuspected no endocrine effect
No effect on reproductice organs weights
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mammalianEffect on estrogen
Reduced seminal vesicles and prostate weights
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mammaliansuspected no endocrine effect
No interaction with ER
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mammaliansuspected no endocrine effect
No induction of ER-mediated activity
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mammalianEffect on estrogen
Dose-dependent uterotrophic activity
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mammalianEffect on estrogen
RBA to [3H]-estradiol < 0.004%
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mammaliansuspected endocrine effect
Male offspring: altered territorial behaviour
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mammalianEffect on estrogen
RTA for ERalpha compared to radiolabeled 17-beta-estradiol (%): 9
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mammalianEffect on estrogen
RTA for ERbeta compared to radiolabeled 17-beta-estradiol (%): 2
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reptilesuspected no endocrine effect
No interaction with ER
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yeastEffect on estrogen
Induction of ER-mediated gene expression
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yeastEffect on estrogen
Induction of ER-mediated gene expression
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yeastsuspected no endocrine effect
No estrogenic activity
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.