ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Pentachlorophenol (PCP)
Physicochemical properties
Chemical name NLPentachloorfenol (PCP)
Chemical name ENPentachlorophenol (PCP)
CAS no87-86-5
UN-
Chemical formulaC6Cl5OH
Molecular weight266,34
Boiling point309-310°C
Melting point191°C
Density1,98
Vapour pressure0,00011 mm Hg at 20°C
Solubility14 mg/l at 20°C
LogKow4,07
PhaseSolid
Notes
Persistenceyes
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
mammalianEffect on estrogen
20% reduction of [3H]17-beta-estradiol binding to ER
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mammalianEffect on androgen
30-40% inhibition of [3H]5-alpha-DHT binding to AR
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mammalianEffect on androgen
20-30% decrease in [3H]5-alpha-DHT binding to SHBG
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mammaliansuspected no endocrine effect
No inhibition of aromatase activity
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mammalianEffect on thyroid hormone
F2 and F3 males: decreased serum T4 levels
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mammalianEffect on thyroid hormone
F3 females: decreased serum T4 levels
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mammaliansuspected no endocrine effect
No effect on serum cortisol, testosterone and estradiol levels
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mammalianEffect on thyroid hormone
Decreased serum T4 levels
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mammaliansuspected endocrine effect
Increased severity of oviductal intraepithelial cysts
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mammalianEffect on thyroid hormone
Decreased serum T4 levels
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mammaliansuspected endocrine effect
Increased thyroid follicle size
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mammaliansuspected no endocrine effect
No induction of cell proliferation
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yeastEffect on progestogen
Inhibition of hPR activity
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yeastEffect on progestogen
Reduction of R5020 binding to hPR
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yeastsuspected no endocrine effect
Cytotoxic
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.