The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels
Geffeney, S.L.; Ruben, P.C. (2006). The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels. Mar. Drugs 4(3): 143-156. https://dx.doi.org/10.3390/md403143
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
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Keywords |
Materials > Hazardous materials > Biological poisons > Neurotoxins Materials > Hazardous materials > Biological poisons > Tetrodotoxin TTX Marine/Coastal |
Authors | | Top |
- Geffeney, S.L.
- Ruben, P.C.
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Abstract |
Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV. |
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