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Effects of methoxychlor, dieldrin and lindane on sea urchin fertilization and early development
Pesando, D.; Robert, S.; Huitorel, P.; Gutknecht, E.; Pereira, L.; Girard, J.-P.; Ciapa, B. (2004). Effects of methoxychlor, dieldrin and lindane on sea urchin fertilization and early development. Aquat. Toxicol. 66(3): 225-239. http://dx.doi.org/10.1016/j.aquatox.2003.09.007
In: Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514, more
Peer reviewed article  

Available in  Authors 

Keywords
    Biological development
    Cells > Sexual cells > Eggs
    Cells > Sexual cells > Sperm
    Chemical compounds > Organic compounds > Hydrocarbons > Halogenated hydrocarbons > Chlorinated hydrocarbons > Dieldrin
    Chemical compounds > Organic compounds > Hydrocarbons > Halogenated hydrocarbons > Chlorinated hydrocarbons > Lindane
    Fertilization
    Organic compounds > Organic halogen compounds > Organochlorine compounds > Pesticides > Organochlorine pesticides > Insecticides > Organochlorine insecticides > Methoxychlor
    Pesticide
    Pesticides
    Reproduction > Cell division > Mitosis
    Reproduction > Sexual reproduction > Biological fertilization
    Reproduction > Sexual reproduction > Fertilization
    Sea urchins
    Sea urchins
    Paracentrotus lividus (Lamarck, 1816) [WoRMS]
    MED, France, Provence-Cote d'Azur, Villefranche-su [Marine Regions]
    Marine/Coastal
Author keywords
    pesticide; methoxychlor; dieldrin; lindane; sea urchin; egg; sperm;fertilization; mitosis; early development

Authors  Top 
  • Pesando, D.
  • Robert, S.
  • Huitorel, P.
  • Gutknecht, E.
  • Pereira, L.
  • Girard, J.-P.
  • Ciapa, B., correspondent

Abstract
    We have studied the effects of methoxychlor (MXC), dieldrin, and lindane on fertilization and early development of sea urchin egg. These organochlorine pesticides have often been found in polluted ground and water near agricultural sites, and have therefore been detected from time to time in the food chain and in drinking water. They have been reported to alter various reproduction functions in various animals including marine populations. We observed that the rate of fertilization decreased when the sperm was incubated with dieldrin or lindane. Treatment of eggs with each pesticide did not prevent fertilization, but increased the rate in polyspermy, delayed or blocked the first mitotic divisions, and altered early embryonic development. Moreover, all pesticides could alter several intracellular biochemical pathways that control first mitotic divisions and early development, including intracellular calcium homeostasis, MPF (mitosis promoting factor) activity and formation of the bipolar mitotic spindle. We found that lindane was the most potent of the three pesticides to alter all biochemical events. All these effects were observed at relatively high concentrations. However, bio-accumulation in sediments and aquatic organisms have been reported. Sea urchin eggs may then be in contact with very high concentrations of these pesticides in areas where these pesticides are not handled or stocked properly, and then develop into abnormal embryos.

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