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Laboratorium voor Toxicologie en Farmacologie (KULeuven)
https://pharm.kuleuven.be/toxipharm
English name: Laboratory for Toxicology and Pharmacology
Parent institute: KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen (KULeuven), more

Address:
O. & N.2
Herestraat 49B 922
3000 Leuven
Belgium
 Persons | Publications | Project 
 
Type: Scientific
Persons (15)  Top | Publications | Project 
Abstract:
The laboratory for Toxicology and Pharmacology of the KU Leuven University conducts research on substances foreign to the body (among which toxins) and studies the safety aspects and the composition of foodstuffs. At the request of the Belgian Court of Justice, the laboratory also performs forensic toxicological analyses and conducts research on biological samples (including post mortem) and confiscated products.

With regard to marine research, the laboratory focuses on the discovery and characterisation of toxins (peptides and small organic molecules) present in poison glands or organs of marine species such as jellyfish, sea anemones and Conus snails. The research group aims to further concentrate on this topic in the future. Within this context, the main challenge is to combine state-of-the-art analytical techniques (for example chromatography, mass spectrometry and sequencing) in order to link proteomics with transcriptomics and functional studies (using electrophysiological assay with voltage clamp on cloned ion channels and receptors).

The laboratory for Toxicology and Pharmacology also participated in the MAREX-project (2010-2014 - EU FP7) on exploring marine resources for bioactive compounds.
Publications (86)  Top | Persons | Project 
    ( 77 peer reviewed ) split up filter
  • Peer reviewed article Sintsova, O.; Gladkikh, I.; Monastyrnaya, M.; Tabakmakher, V.; Yurchenko, E.; Menchinskaya, E.; Pislyagin, E.; Andreev, Y.; Kozlov, S.; Peigneur, S.; Tytgat, J.; Aminin, D.; Kozlovskaya, E.; Leychenko, E. (2021). Sea anemone Kunitz-type peptides demonstrate neuroprotective activity in the 6-hydroxydopamine induced neurotoxicity model. Biomedicines 9(3): 283. https://hdl.handle.net/10.3390/biomedicines9030283, more
  • Peer reviewed article Gladkikh, I.; Peigneur, S.; Sintsova, O.; Pinheiro-Junior, E.L.; Klimovich, A.; Menshov, A.; Kalinovsky, A.; Isaeva, M.; Monastyrnaya, M.; Kozlovskaya, E.; Tytgat, J.; Leychenko, E. (2020). Kunitz-type peptides from the sea anemone Heteractis crispa demonstrate potassium channel blocking and anti-inflammatory activities. Biomedicines 8(11): 473. https://hdl.handle.net/10.3390/biomedicines8110473, more
  • Peer reviewed article Kalina, R.S.; Peigneur, S.; Zelepuga, E.A.; Dmitrenok, P.S.; Kvetkina, A.N.; Kim, N.Y.; Leychenko, E.V.; Tytgat, J.; Kozlovskaya, E.P.; Monastyrnaya, M.M.; Gladkikh, I.N. (2020). New insights into the type II toxins from the sea anemone Heteractis crispa. Toxins 12(1): 44. https://hdl.handle.net/10.3390/toxins12010044, more
  • Peer reviewed article Kalina, R.S.; Peigneur, S.; Gladkikh, I.N.; Dmitrenok, P.S.; Kim, N.Y.; Leychenko, E.V.; Monastyrnaya, M.M.; Tytgat, J.; Kozlovskaya, E.P. (2020). New sea anemone toxin RTX-VI selectively modulates voltage-gated sodium channels. Doklady Biochemistry and Biophysics 495(1): 292-295. https://hdl.handle.net/10.1134/S1607672920060071, more
  • Peer reviewed article Kvetkina, A.; Leychenko, E.; Chausova, V.; Zelepuga, E.; Chernysheva, N.; Guzev, K.; Pislyagin, E.; Yurchenko, E.; Menchinskaya, E.; Aminin, D.; Kaluzhskiy, L.; Ivanov, A.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E.; Isaeva, M. (2020). A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine. NPG Scientific Reports 10(1): 4205. https://hdl.handle.net/10.1038/s41598-020-61034-x, more
  • Peer reviewed article Schmidt, C.A.; Wilson, D.T.; Cooke, I.; Potriquet, J.; Tungatt, K.; Muruganandah, V.; Boote, C.; Kuek, F.; Miles, J.J.; Kupz, A.; Ryan, S.; Loukas, A.; Bansal, P.S.; Takjoo, R.; Miller, D.J.; Peigneur, S.; Tytgat, J.; Daly, N.L. (2020). Identification and characterization of a peptide from the stony coral Heliofungia actiniformis. J. Nat. Prod. 83(11): 3454-3463. https://hdl.handle.net/10.1021/acs.jnatprod.0c00981, more
  • Peer reviewed article Andersson, H.S.; Jacobsson, E.; Strand, M.; Peigneur, S.; Lebbe, E.K.M.; Rosengren, K.J.; Goransson, U.; Tytgat, J. (2019). α-nemertides, a novel family of marine peptide neurotoxins from ribbon worms. Toxicon 158(S1): S38-S39. https://hdl.handle.net/10.1016/j.toxicon.2018.10.136, more
  • Peer reviewed article Collins, J.E.; Harden-Davies, H.; Jaspars, M.; Thiele, T.; Vanagt, T.; Huys, I. (2019). Inclusive innovation: Enhancing global participation in and benefit sharing linked to the utilization of marine genetic resources from areas beyond national jurisdiction. Mar. Policy 109: 103696. https://dx.doi.org/10.1016/j.marpol.2019.103696, more
  • Peer reviewed article Elnahriry, K.A.; Wai, D.C.C.; Krishnarjuna, B.; Badawy, N.N.; Chittoor, B.; MacRaild, C.A.; Williams-Noonan, B.J.; Surm, J.M.; Chalmers, D.K.; Zhang, A.H.; Peigneur, S.; Mobli, M.; Tytgat, J.; Prentis, P.; Norton, R.S. (2019). Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon 168: 104-112. https://dx.doi.org/10.1016/j.toxicon.2019.07.002, more
  • Peer reviewed article Gladkikh, I.; Kalina, R.; Sinsova, O.; Kvetkina, A.; Peigneur, S.; Koshelev, S.; Kim, N.; Monastyrnaya, M.; Kozlov, S.; Tytgat, J.; Kozlovskaya, E. (2019). New Kv, NAv, and ASIC channel toxins from the sea anemone Heteractis crispa. Toxicon 158(S1): S48-S48. https://hdl.handle.net/10.1016/j.toxicon.2018.10.168, more
  • Peer reviewed article Kalina, R.; Gladkikh, I.; Peigneur, S.; Dmitrenok, P.; Zelepuga, E.; Monastyrnaya, M.; Kozlovskaya, E. (2019). Type II toxins from sea anemone Heteractis crispa with various effects on activation and inactivation of voltage-gated sodium channels. Toxicon 159(S1): S18-S18. https://hdl.handle.net/10.1016/j.toxicon.2018.11.376, more
  • Peer reviewed article Peigneur, S.; Devi, P.; Seldeslachts, A.; Ravichandran, S.; Quinton, L.; Tytgat, J. (2019). Structure-function elucidation of a new α-conotoxin, MiIIA, from Conus milneedwardsi. Mar. Drugs 17(9): 535. https://dx.doi.org/10.3390/md17090535, more
  • Peer reviewed article Peigneur, S.; Cheneval, O.; Maiti, M.; Leipold, E.; Heinemann, S.H.; Lescrinier, E.; Herdewijn, P.; de Lima, M.E.; Craik, D.J.; Schroeder, C.I.; Tytgat, J. (2019). Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB J. 33(3): 3693-3703. https://dx.doi.org/10.1096/fj.201801909R, more
  • Peer reviewed article Sachkova, M.Y.; Singer, S.A.; Macrander, J.; Reitzel, A.M.; Peigneur, S.; Tytgat, J.; Moran, Y. (2019). The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella. Mol. Biol. Evol. 36(9): 2001-2012. https://dx.doi.org/10.1093/molbev/msz132, more
  • Peer reviewed article Sintsova, O.; Kalinovskii, A.; Gladkikh, I.; Zelepuga, E.; Monastyrnaya, M.; Kim, N.; Shevchenko, L.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E.; Leychenko, E. (2019). Magnificamide, a β-defensin-like peptide from the mucus of the sea anemone Heteractis magnifica, is a strong inhibitor of mammalian α-amylases. Mar. Drugs 17(10): 542. https://dx.doi.org/10.3390/md17100542, more
  • Peer reviewed article Zelepuga, E.; Gladkikh, I.; Peigneur, S.; Tytgat, J.; Monastyrnaya, M.; Kozlovskaya, E. (2019). The Kunitz-type HCRG peptides from the sea anemone Heteractis crispa possess Kv channel toxicity. Toxicon 159(S1): S26-S27. https://hdl.handle.net/10.1016/j.toxicon.2018.11.408, more
  • Peer reviewed article Jacobsson, E.; Andersson, H.S.; Strand, M.; Peigneur, S.; Eriksson, C.; Loden, H.; Shariatgorji, M.; Andren, P.E.; Lebbe, E.K.M.; Rosengren, K.J.; Tytgat, J.; Goransson, U. (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. NPG Scientific Reports 8: 10. https://dx.doi.org/10.1038/s41598-018-22305-w, more
  • Peer reviewed article Krishnarjuna, B.; MacRaild, C.A.; Sunanda, P.; Morales, R.A.V.; Peigneur, S.; Macrander, J.; Yu, H.H.; Daly, M.; Raghothama, S.; Chauhan, S.; Tytgat, J.; Pennington, M.W.; Norton, R.S. (2018). Corrigendum to“Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK”[Peptides 99 (2018) 169–178]. Peptides (New York, NY : 1980) 101: 234-234. https://dx.doi.org/10.1016/j.peptides.2018.01.008, more
  • Peer reviewed article Krishnarjuna, B.; MacRaild, C.A.; Sunanda, P.; Morales, R.A.V.; Peigneur, S.; Macrander, J.; Yu, H.H.; Daly, M.; Raghothama, S.; Dhawan, V.; Chauhan, S.; Tytgat, J.; Pennington, M.W.; Norton, R.S. (2018). Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK. Peptides (New York, NY : 1980) 99: 169-178. https://dx.doi.org/10.1016/j.peptides.2017.10.001, more
  • Peer reviewed article Krishnarjuna, B.; Villegas-Moreno, J.; Mitchell, M.L.; Csoti, A.; Peigneur, S.; Amero, C.; Pennington, M.W.; Tytgat, J.; Panyi, G.; Norton, R.S. (2018). Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold. Toxicon 150: 50-59. https://dx.doi.org/10.1016/j.toxicon.2018.05.006, more
  • Peer reviewed article Madio, B.; Peigneur, S.; Chin, Y.K.Y.; Hamilton, B.; Henriques, S.T.; Smith, J.J.; Cristofori-Armstrong, B.; Dekan, Z.; Boughton, B.A.; Alewood, P.F.; Tytgat, J.; King, G.F.; Undheim, E.A.B. (2018). PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular and molecular life sciences 75(24): 4511-4524. https://dx.doi.org/10.1007/s00018-018-2897-6, more
  • Peer reviewed article Orts, D.J.B.; Peigneur, S.; Silva-Goncalves, L.C.; Arcisio-Miranda, M.; Bicudo, J.E.P.W.; Tytgat, J. (2018). AbeTx1 is a novel sea anemone toxin with a dual mechanism of action on Shaker-type K+ channels activation. Mar. Drugs 16(10): 360. https://dx.doi.org/10.3390/md16100360, more
  • Peer reviewed article Peigneur, S.; de Lima, M.E.; Tytgat, J. (2018). Phoneutria nigriventer venom: a pharmacological treasure. Toxicon 151: 96-110. https://dx.doi.org/10.1016/j.toxicon.2018.07.008, more
  • Peer reviewed article Rodríguez, A.A.; Garateix, A.; Salceda, E.; Peigneur, S.; Zaharenko, A.J.; Pons, T.; Santos, Y.; Arreguin, R.; Ständker, L.; Forssmann, W.-G.; Tytgat, J.; Vega, R.; Soto, E. (2018). PhcrTx2, a new crab-paralyzing peptide toxin from the sea anemone Phymanthus crucifer. Toxins 10(2): 72. https://dx.doi.org/10.3390/toxins10020072, more
  • Peer reviewed article Sunanda, P.; Krishnarjuna, B.; Peigneur, S.; Mitchell, M.L.; Estrada, R.; Villegas-Moreno, J.; Pennington, M.W.; Tytgat, J.; Norton, R.S. (2018). Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp. Peptide Science 110(4): e24073. https://dx.doi.org/10.1002/pep2.24073, more
  • Peer reviewed article Montero-Alejo, V.; Corzo, G.; Porro-Suardiaz, J.; Pardo-Ruiz, Z.; Perera, E.; Rodriguez-Viera, L.; Sanchez-Diaz, G.; Alvarez, C.; Peigneur, S.; Tytgat, J.; Perdomo-Morales, R. (2017). Panusin represents a new family of β-defensin-like peptides in invertebrates. Dev. Comp. Immunol. 67: 310-321. https://dx.doi.org/10.1016/j.dci.2016.09.002, more
  • Peer reviewed article Moreels, L.; Bhat, C.; Vorácová, M.; Peigneur, S.; Mäki-Lohiluoma, E.; Zahed, F.; Pardo, L.A.; Yli-Kauhaluoma, J.; Kiuru, P.; Tytgat, J. (2017). Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancerrelevant potassium channel KV10.1. PLoS One 12(12): e0188811. https://dx.doi.org/10.1371/journal.pone.0188811, more
  • Peer reviewed article Moreels, L.; Peigneur, S.; Galan, D.T.; De Pauw, E.; Béress, L.; Waelkens, E.; Pardo, L.A.; Quinton, L.; Tytgat, J. (2017). APETx4, a novel sea anemone toxin and a modulator of the cancer-relevant potassium channel KV10.1. Mar. Drugs 15(9): 287. https://dx.doi.org/10.3390/md15090287, more
  • Peer reviewed article Zidar, N.; Zula, A.; Tomašic, T.; Rogers, M.; Kirby, R.W.; Tytgat, J.; Peigneur, S.; Kikelj, D.; Ilas, J.; Masic, L.P. (2017). Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur. J. Med. Chem. 139: 232-241. https://dx.doi.org/10.1016/j.ejmech.2017.08.015, more
  • Peer reviewed article García-Fernández, R.; Peigneur, S.; Pons, T.; Alvarez, C.; González, L.; Chávez, M.A.; Tytgat, J. (2016). The Kunitz-type protein ShPI-1 inhibits serine proteases and voltage-gated potassium channels. Toxins 8(4): 110. dx.doi.org/10.3390/toxins8040110, more
  • Peer reviewed article Kopljar, I.; Grottesi, A.; de Block, T.; Rainier, J.D.; Tytgat, J.; Labro, A.J.; Snyders, D.J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology 107: 160-167. https://dx.doi.org/10.1016/j.neuropharm.2016.03.010, more
  • Peer reviewed article Lebbe, E.K.M.; Ghequire, M.G.K.; Peigneur, S.; Mille, B.G.; Devi, P.; Ravichandran, S.; Waelkens, E.; D'Souza, L.; De Mot, R.; Tytgat, J. (2016). Novel conopeptides of largely unexplored Indo Pacific Conus sp. Mar. Drugs 14(11): 18 pp. https://dx.doi.org/10.3390/md14110199, more
  • Peer reviewed article Lebbe, E.K.M.; Tytgat, J. (2016). In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds. Journal of Venomous Animals and Toxins Including Tropical Diseases 22: 15 pp. https://dx.doi.org/10.1186/s40409-016-0083-6, more
  • Peer reviewed article Martínez-Morales, E.; Kopljar, I.; Rainier, J.D.; Tytgat, J.; Snyders, D.J.; Labro, A.J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon 120: 57-60. https://dx.doi.org/10.1016/j.toxicon.2016.07.017, more
  • Peer reviewed article Monastyrnaya, M.; Peigneur, S.; Zelepuga, E.; Sintsova, O.; Gladkikh, I.; Leychenko, E.; Isaeva, M.; Tytgat, J.; Kozlovskaya, E. (2016). Kunitz-type peptide HCRG21 from the sea anemone Heteractis crispa is a full antagonist of the TRPV1 receptor. Mar. Drugs 14(12): 229. https://dx.doi.org/10.3390/md14120229, more
  • Peer reviewed article Jukic, M.; Frlan, R.; Chan, F.; Kirby, R.; Madge, D.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D. (2015). Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators. Med. Chem. Res. 24(6): 2366-2380. dx.doi.org/10.1007/s00044-014-1300-x, more
  • Peer reviewed article Sintsova, O.; Chausova, V.; Gladkikh, I.; Isaeva, M.; Tabakmaher, V.; Monastyrnaya, M.; Leychenko, E.; Pislyagin, E.; Menchinskaya, E.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). New antihistamine Kunitz-type polypeptides of the sea anemones, Heteractis crispa and Stichodactyla mertensii. The FEBS Journal 282(Suppl. 1): 140-141, more
  • Peer reviewed article Zelepuga, E.; Gladkikh, I.; Monastyrnaya, M.; Sintsova, O.; Tabakmaher, V.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). The sea anemone Heteractis crispa - a source of potential pharmacological agents. The FEBS Journal 282(Suppl. 1): 322-323, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P.; Ravichandran, S.; Lescrinier, E.; Ulens, C.; Waelkens, E.; D'Souza, L.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. 289(14): 9573-9583. https://dx.doi.org/10.1074/jbc.M114.556175, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Wijesekara, I.; Tytgat, J. (2014). Conotoxins targeting nicotinic acetylcholine receptors: an overview. Mar. Drugs 12(5): 2970-3004. dx.doi.org/10.3390/md12052970, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P; Ravichandran, S; D'Souza, L; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. Toxicon 91: 170-171. dx.doi.org/10.1016/j.toxicon.2014.08.023, more
  • Peer reviewed article Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Mille, B.G.; Devi, P; Ravichandran, S; Lescrinier, E.; Waelkens, E.; D'Souza, L; Herdewijn, P.; Tytgat, J. (2014). Discovery of a new subclass of alpha-conotoxins in the venom of Conus australis. Toxicon 91: 145-154. https://dx.doi.org/10.1016/j.toxicon.2014.08.074, more
  • Peer reviewed article Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J. (2014). Action of Clathrodin and analogues on voltage-gated sodium channels. Mar. Drugs 12(4): 2132-2143. dx.doi.org/10.3390/md12042132, more
  • Peer reviewed article Peigneur, S.; Tytgat, J. (2014). When cone snails and spiders meet: design of selective and potent sodium channel inhibitors. Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.022, more
  • Peer reviewed article Rodriguez, A; Salceda, E; Garateix, G; Zaharenko, J; Peigneur, S.; Lopez, O; Pons, T; Richardson, M; Diaz, M; Hernandez, Y; Standker, L; Tytgat, J.; Soto, E (2014). A novel sea anemone peptide that inhibits acid-sensing ion channels. Peptides (New York, NY : 1980) 53: 3-12. dx.doi.org/10.1016/j.peptides.2013.06.003, more
  • Peer reviewed article Tytgat, J. (2014). Sea anemone toxins: from lab bench discovery to commercial drugs? Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.021, more
  • Peer reviewed article Wijesekara, I.; Peigneur, S.; Devi, P; Ravichandran, S; Lebbe, E.; Mille, B.; D'Souza, L; Tytgat, J. (2014). Isolation and characterization of novel conopeptides from Conus amadis that target voltage-gated sodium channels. Toxicon 91: 184-184. dx.doi.org/10.1016/j.toxicon.2014.08.056, more
  • Peer reviewed article Zhu, S.; Peigneur, S.; Gao, B.; Umetsu, Y.; Ohki, S.; Tytgat, J. (2014). Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function. Mol. Biol. Evol. 31(3): 546-559. https://dx.doi.org/10.1093/molbev/msu038, more
  • Peer reviewed article Zidar, N.; Jakopin, Z.; Madge, D.; Chan, F.; Tytgat, J.; Peigneur, S.; Dolenc, M.; Tomasic, T.; Ilas, J.; Masic, L.; Kikelj, D. (2014). Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators. Eur. J. Med. Chem. 74: 23-30. dx.doi.org/10.1016/j.ejmech.2013.12.034, more
  • Peer reviewed article Bergeron, Z.L.; Chun, J.B.; Baker, M.R.; Sandall, D.W.; Peigneur, S.; Yu, P.Y.C.; Thapa, P.; Milisen, J.W.; Tytgat, J.; Livett, B.G.; Bingham, J.P. (2013). A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile-The pharmacological importance of post-translational modifications. Peptides (New York, NY : 1980) 49: 145-158. dx.doi.org/10.1016/j.peptides.2013.09.004, more
  • Peer reviewed article Cassoli, J.; Verano-Braga, T.; Oliveira, J.; Montandon, G.; Cologna, C.T.; Peigneur, S.; Pimenta, A.; Kjeldsen, F.; Roepstorff, P.; Tytgat, J.; de Lima, M. (2013). The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide. J. Proteomics 87: 89-102. https://dx.doi.org/10.1016/j.jprot.2013.05.022, more
  • Peer reviewed article Kendel, Y.; Melaun, C.; Kurz, A.; Nicke, A.; Peigneur, S.; Tytgat, J.; Wunder, C.; Mebs, D.; Kauferstein, S. (2013). Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. Toxins 5(5): 1043-1050. dx.doi.org/10.3390/toxins5051043, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.; Tytgat, J.; Snyders, D.J. (2013). The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J. Gen. Physiol. 141(3): 359-369. https://dx.doi.org/10.1085/jgp.201210890, more
  • Peer reviewed article Orts, D.J.B.; Peigneur, S.; Madio, B.; Cassoli, J.S.; Montandon, G.G.; Pimenta, A.M.C.; Bicudo, J.E.P.W.; Freitas, J.C.; Zaharenko, A.J.; Tytgat, J. (2013). Biochemical and electrophysiological characterization of two sea anemone Type 1 Potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar. Drugs 11(3): 655-679. dx.doi.org/10.3390/md11030655, more
  • Peer reviewed article Orts, D.J.B.; Moran, Y.; Cologna, C.T.; Peigneur, S.; Madio, B.; Praher, D.; Quinton, L.; De Pauw, E.; Bicudo, J.E.P.W.; Tytgat, J.; de Freitas, J.C. (2013). BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker. The FEBS Journal 280(19): 4839-4852. dx.doi.org/10.1111/febs.12456, more
  • Peer reviewed article Peigneur, S.; Van Der Haegen, A.; Möller, C.; Waelkens, E.; Diego-García, E.; Marí, F.; Naudé, R.; Tytgat, J. (2013). Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (New York, NY : 1980) 41: 8-16. https://dx.doi.org/10.1016/j.peptides.2012.07.002, more
  • Peer reviewed article Tomašic, T.; Hartzoulakis, B.; Zidar, N.; Chan, F.; Kirby, R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. (2013). Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators. Journal of Chemical Information and Modeling 53(12): 3223-3232. https://dx.doi.org/10.1021/ci400505e, more
  • Peer reviewed article Gladkikh, I.; Monastyrnaya, M.; Leychenko, E.; Zelepuga, E.; Chausova, V.; Isaeva, M.; Anastyuk, S.; Andreev, Y.; Peigneur, S.; Tytgat, J.; Kozlovkaya, E. (2012). Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa. Mar. Drugs 10(7): 1545-1565. http://dx.doi.org/10.3390/md10071545, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2012). Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin Gambierol. Toxicon 60(2): 150-151. dx.doi.org/10.1016/j.toxicon.2012.04.111, more
  • Peer reviewed article Peigneur, S.; Lescrinier, E.; Moller, C.; Mari, F.; Beress, L.; Tytgat, J. (2012). A natural point mutation reveals target promiscuity of toxins isolated from the sea anemone Anthopleura elegantissima. Biophys. J. 102(3, Supplement 1): 658A-658A, more
  • Peer reviewed article Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2012). A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 26(12): 5141-5151. http://dx.doi.org/10.1096/fj.12-218479, more
  • Peer reviewed article Stevens, M.; Peigneur, S.; Dyubankova, N.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Design of bioactive peptides from naturally occurring µ-conotoxin structures. J. Biol. Chem. 287(37): 31382-31392. dx.doi.org/10.1074/jbc.M112.375733, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Dyubankova, N.; Moller, C.; Mari, F.; Diego-García, E.; Naude, R.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity. Peptides (New York, NY : 1980) 34(1): 106-113. dx.doi.org/10.1016/j.peptides.2011.10.026, more
  • Peer reviewed article Cuypers, E.; Peigneur, S.; Debaveye, S.; Shiomi, K.; Tytgat, J. (2011). TRPV1 channel as new target for marine toxins: Example of gigantoxin I, a sea anemone toxin acting via modulation of the PLA2 pathway. Acta Chim. Slov. 58(4): 735-741, more
  • Peer reviewed article Peigneur, S.; Billen, B.; Derua, R.; Waelkens, E.; Debaveye, S.; Béress, L.; Tytgat, J. (2011). A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem. Pharmacol. 82(1): 81-90. https://dx.doi.org/10.1016/j.bcp.2011.03.023, more
  • Peer reviewed article Van Der Haegen, A.; Peigneur, S.; Tytgat, J. (2011). Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. The FEBS Journal 278(18): 3408-3418. dx.doi.org/10.1111/j.1742-4658.2011.08264.x, more
  • Peer reviewed article Billen, B.; Debaveye, S.; Béress, L.; Garateixand, A.; Tytgat, J. (2010). Phyla- and subtype-selectivity of CgNa, a Na+ channel toxin from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea. Front. Pharmacol. 1: 133. http://dx.doi.org/10.3389/fphar.2010.00133, more
  • Peer reviewed article Kopljar, I.; Labro, A.J.; Cuypers, E.; Johnson, H.W.B.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2009). A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc. Natl. Acad. Sci. U.S.A. 106(24): 9896-9901. http://dx.doi.org/10.1073/pnas.0812471106, more
  • Peer reviewed article Cuypers, E.; Abdel-Mottaleb, Y.; Kopljar, I.; Rainier, J.; Raes, A.L.; Snyders, D.J.; Tytgat, J. (2008). Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon 51(6): 974-983. https://dx.doi.org/10.1016/j.toxicon.2008.01.004, more
  • Peer reviewed article Bosmans, F.; Tytgat, J. (2007). Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. Toxicon 49(4): 550-560. dx.doi.org/10.1016/j.toxicon.2006.11.029, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. (2007). TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem. Biophys. Res. Commun. 361(1): 214-217. dx.doi.org/10.1016/j.bbrc.2007.07.009, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2007). Corrigendum to "Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels" [FEBS Lett. 580 (2006) 5728-5732]. FEBS Lett. 581(8): 1699. dx.doi.org/10.1016/j.febslet.2007.03.036, more
  • Peer reviewed article Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2006). Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett. 580(24): 5728-5732. dx.doi.org/10.1016/j.febslet.2006.09.030, more
  • Peer reviewed article Kauferstein, S.; Huys, I.; Kuch, U.; Melaun, C.; Tytgat, J.; Mebs, D. (2004). Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon 44(5): 539-548, more
  • Peer reviewed article Fan, C.X.; Chen, X.K.; Zhang, C.; Wang, L.X.; Duan, K.L.; He, L.L.; Cao, Y.; Liu, S.Y.; Zhong, M.N.; Ulens, C.; Tytgat, J.; Chen, J.S.; Chi, C.W.; Zhou, Z. (2003). A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J. Biol. Chem. 278(15): 12624-12633, more
  • Peer reviewed article Bosmans, F.; Aneiros, A.; Tytgat, J. (2002). The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett. 532(1-2): 131-134. dx.doi.org/10.1016/S0014-5793(02)03653-0, more
  • Peer reviewed article Goudet, C.; Ferrero, T.; Galàn, L.; Artiles, A.; Batista, C.F.V.; Possani, L.D.; Alvarez, J.; Aneiros, A.; Tytgat, J. (2001). Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels. Br. J. Pharmacol. 134(6): 1195-1206. dx.doi.org/10.1038/sj.bjp.0704361, more
  • De Raedemaecker, F.; Sandra, M.; Devriese, L; Goeminne, G.; Bicalho, K.; Montoye, T.; Tytgat, J.; Bernaerts, H.; Coenye, T.; Van Vlierberghe, W.; Loosvelt , L. (2021). Prospection for bioactive compounds in the North Sea: Creating a knowledge base for blue biotech innovation in Flanders, in: Mees, J. et al. Book of abstracts – VLIZ Marine Science Day, Online event 3 March 2021. VLIZ Special Publication, 85: pp. 45, more
  • De Raedemaecker, F.; Sandra, M.; Devriese, L.I.; Goeminne, G.; Bicalho, K.; Montoye, T.; Tytgat, J.; Bernaerts, H.; Loosvelt , L. (2021). PROspectionfor BIOactivecompounds in the North Sea (PROBIO): creating a knowledge base for blue biotech innovation in Flanders. Poster submited at VLIZ Marine Science Day, Online event 3 March 2021. VLIZ/KU Leuven/Universiteit Gent: Oostende. 1 poster pp., more
  • Tytgat, J. (2017). α-Nemertides, a novel family of marine peptide neurotoxins from ribbon worms. KULeuven: Leuven. , more
  • Kopljar, I.; Peigneur, S.; Snyders, D.J.; Tytgat, J. (2014). The mechanism of action of microalgal toxins interacting with Nav and Kv channels, in: Rossini, G.P. (Ed.) Toxins and biologically active compounds from microalgae: Volume 2. Biological effects and risk management. pp. 3-34, more
  • Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2013). Sea anemone toxins: insecticides and painkillers of the future?, in: Mees, J. et al. (Ed.) Marine biotechnology in the European research area: Challenges and opportunities for Europe. Final CSA MarineBiotech Conference. Royal Flemish Academy of Belgium for Science and the Arts, Brussels, Belgium, 11-12 March 2013. VLIZ Special Publication, 64: pp. 7, more
  • Tytgat, J. (2009). Expectancies of a toxicologist: from sudden poisoning to miraculous discovery, in: Mees, J. et al. (Ed.) VLIZ Young Scientists' Day, Brugge, Belgium 6 March 2009: book of abstracts. VLIZ Special Publication, 41: pp. 14, more
  • Tytgat, J. (2008). Toxines van kwallen en zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Prijs Dr. E. Delcroix 2007 - 11 april 2008, Oostende. [S.n.]: [s.l.]. 1 presentation [52 Slides] pp., more
  • Tytgat, J. (2007). Toxines van kwallen en zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Katholieke Universiteit Leuven. Faculteit Farmaceutische Wetenschappen. Laboratorium Toxicologie: Leuven. 23 pp., more
  • Tytgat, J. (2007). Toxins from jellyfish and sea anemones: a 'sea' of molecules with therapeutic potential. KU Leuven, Laboratorium Toxicologie: Leuven. 23 pp., more
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  • PROBIO: PROspection for BIOactive compounds in the North Sea, more
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