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Anti-tumor marine natural products
Kitagawa, I.; Kobayashi, M. (1990). Anti-tumor marine natural products. Gan to Kagaku Ryoho = Japanese Journal of Cancer and Chemotherapy 17(3): 322-329
In: Gan to Kagaku Ryoho = Japanese Journal of Cancer and Chemotherapy. Cancer and Chemotherapy Publishing Company: Tokyo. ISSN 0385-0684, more
Peer reviewed article  

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Author keywords
    Marine natural products; Marine anti-tumor substance; Didemnin B; Bryostatin; Dolastatin

Authors  Top 
  • Kitagawa, I.
  • Kobayashi, M.

    In anticipation of developing new anti-cancer drugs from marine organisms of rich species, a variety of anti-tumor substances having diverse chemical structures have been discovered. Among those marine anti-tumor substances, which were reviewed in a previous paper [Jpn. J. Cancer Chemother., 16, 1-8 (1989)], several compounds promising as anti-cancer drugs are detailed in this article. They are didemnin B from marine tunicate, bryostatin 1 from marine bryozoa, and dolastatin 10 from sea hare. In addition, several anti-tumor marine sponge constituents: halichondrin B, calyculin A, and mycalamides A and B, are briefly reviewed.

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