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Genomics of megavirus and the elusive fourth domain of Life
Legendre, M.; Arslan, D.; Abergel, C.; Claverie, J.M. (2012). Genomics of megavirus and the elusive fourth domain of Life. Communicative & Integrative Biology 5(1): 102-106. https://dx.doi.org/10.4161/cib.18624
In: Communicative & Integrative Biology. TAYLOR & FRANCIS INC: Philadelphia. ISSN 1942-0889, more
Peer reviewed article  

Available in  Authors 

Keyword
    Megaviridae
Author keywords
    Girus, Megaviridae, Short read sequencing, Tree of Life

Authors  Top 
  • Legendre, M.
  • Arslan, D.
  • Abergel, C.
  • Claverie, J.M.

Abstract
    We recently described Megavirus chilensis, a giant virus isolated off the coast of Chile, also replicating in fresh water acanthamoeba. Its 1,259,197-bp genome encodes 1,120 proteins and is the largest known viral genome. Megavirus and its closest relative Mimivirus only share 594 orthologous genes, themselves sharing only 50% of identical residues in average. Despite this divergence, comparable to the maximal divergence exhibited by bacteria within the same division (e.g., gamma proteobacteria), Megavirus retained all of the genomic features unique to Mimivirus, in particular its genes encoding key-elements of the translation apparatus, a trademark of cellular organisms. Besides homologs to the four aminoacyl-tRNA synthetases (aaRS) encoded by Mimivirus, Megavirus added three additional ones, raising the total of known virus-encoded aaRS to seven: IleRS, TrpRS, AsnRS, ArgRS, CysRS, MetRS, TyrRS. This finding strongly suggests that large DNA viruses derived from an ancestral cellular genome by reductive evolution. The nature of this cellular ancestor remains hotly debated.

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