IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (1): add | show Print this page

one publication added to basket [331164]
Effects of Agelas oroides and Petrosia ficiformis crude extracts on human neuroblastoma cell survival
Ferretti, C.; Marengo, B.; De Ciucis, C.; Nitti, M.; Pronzato, M.; Marinari, U.; Pronzato, R.; Manconi, R.; Domenicotti, C. (2007). Effects of Agelas oroides and Petrosia ficiformis crude extracts on human neuroblastoma cell survival. International Journal of Oncology 30(1): 161-169. https://hdl.handle.net/10.3892/ijo.30.1.161
In: International Journal of Oncology: Athens. ISSN 1019-6439; e-ISSN 1791-2423, more
Peer reviewed article  

Available in  Authors | Dataset 

Keywords
    Agelas oroides (Schmidt, 1864) [WoRMS]; Petrosia ficiformis (Poiret, 1789) [WoRMS]
    Marine

Authors  Top | Dataset 
  • Ferretti, C.
  • Marengo, B.
  • De Ciucis, C.
  • Nitti, M.
  • Pronzato, M.
  • Marinari, U.
  • Pronzato, R.
  • Manconi, R., more
  • Domenicotti, C.

Abstract
    Among marine sessile organisms, sponges (Porifera) are the major producers of bioactive secondary metabolites that defend them against predators and competitors and are used to interfere with the pathogenesis of many human diseases. Some of these biological active metabolites are able to influence cell survival and death, modifying the activity of several enzymes involved in these cellular processes. These natural compounds show a potential anticancer activity but the mechanism of this action is largely unknown. In this study, we investigated the effects of two Mediterranean sponges, Agelas oroides and Petrosia ficiformis on the viability of human neuroblastoma cells. Upon treatment with the methanolic extract of Petrosia ficiformis, a marked cytotoxic effect was observed at any concentration or time of exposure. In contrast, a time- and dose-dependent effect was monitored for Agelas oroides that induced the development of apoptotic features and ROS production in LAN5 cells. These events were suppressed by calpeptin or zVAD and by vitamin C suggesting that the cell death caused by Agelas oroides was calpain- and caspase-dependent and of oxidative nature. Comet assay showed that this methanolic extract was not able to produce a genotoxic effect. Future studies will be applied to investigate the effect of isolated bioactive compounds from crude extract of this sponge which are potentially useful for cancer therapeutics.

Dataset
  • CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019., more

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors | Dataset