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Gracilosulfates A–G, monosulfated polyoxygenated steroids from the marine sponge Haliclona gracilis
Shubina, L.K.; Makarieva, T.N.; Denisenko, V.A.; Popov, R.S.; Dyshlovoy, S.A.; Grebnev, B.B.; Dmitrenok, P.S.; von Amsberg, G.; Stonik, V.A. (2020). Gracilosulfates A–G, monosulfated polyoxygenated steroids from the marine sponge Haliclona gracilis. Mar. Drugs 18(9): 454. https://dx.doi.org/10.3390/md18090454
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Haliclona gracilis (Miklucho-Maclay, 1870) [WoRMS]; Porifera [WoRMS]
Author keywords
    polyoxygenated steroids, sponge, anticancer activity

Authors  Top 
  • Shubina, L.K.
  • Makarieva, T.N.
  • Denisenko, V.A.
  • Popov, R.S.
  • Dyshlovoy, S.A.
  • Grebnev, B.B.
  • Dmitrenok, P.S.
  • von Amsberg, G.
  • Stonik, V.A.

Abstract
    Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A–G (1–7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structures were determined by NMR and MS methods. The compounds 1, 2, 4, 6, and 7 inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.

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