ED North Database | Lindane (gamma-Hexachlorocyclohexane) |
Study details | Group | mammalian | Organism | Fischer-344 rat, female | Tissue | | Age | 21 days | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | Chronic | Route | Intraperitoneal | Temperature | | Concentration | LOEL = 40 mg/kg/day | Notes | Cocncentration range: 5-40 mg/kg/day |
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Described effects | | Effect on anti-estrogen: Delayed vaginal opening and disrupted ovarian cycle | | suspected endocrine effect Reduced pituitary and uterus weight |
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Literature references | Chadwick, R.W., Cooper, R.L., Chang, J., Rehnberg, G.L., McElroy, W.K.(1988). Possible antiestrogenic activity of Lindane in Female Rats.J. Biochem. Toxicol., 3: 147-158 |
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