ED North Database | Lindane (gamma-Hexachlorocyclohexane) |
Study details | Group | mammalian | Organism | Rat, male offspring | Tissue | | Age | | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | | Route | Mother milk | Temperature | | Concentration | 6 mg/kg | Notes | Single dose to mother on day 9 or 14 of lactation |
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Described effects | | suspected endocrine effect At adulthood: reduced testicular weight | | Effect on anti-androgen: At adulthood: reduced number of sperm and spermatids | | Effect on anti-androgen: At adulthood and puberty: reduced serum testosterone levels |
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Literature references | Dalsenter, P.R., Faqi, A.S., Webb, J., Merker, H.J., Chahoud, I.(1997). Reproductive Toxicity and Toxicokinetics of Lindane in the Male Offspring of Rats Exposed during Lactation.Hum. Exp. Toxicol., 16: 146-153 |
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