ED North Database | Simazine |
Study details | Group | mammalian | Organism | Sprague-Dawley rat, female | Tissue | | Age | 10-13 weeks | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 2 weeks | Route | Oral | Temperature | | Concentration | 100-300 mg/kg/day | Notes | |
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Described effects | | suspected endocrine effect Prolongation of estrous cycle: increase of days in estrus, decrease of days in diestrus | | suspected endocrine effect Cornification of vaginal epithelium | | Effect on anti-estrogen: Decrease in circulating estradiol levels |
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Literature references | Eldridge, J.C., Fleenor-Heyser, D.G., Extrom, P.C., Wetzel, L.T., Breckenridge, C.B., Gillis, J.H. et al.(1994). Short-term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats.J. Toxicol. Environ. Health, 43:155-167 |
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