ED North Database | PCB |
Study details | Group | mammalian | Organism | Sprague-Dawley rat, female | Tissue | | Age | 21 days | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 2 days | Route | Intraperitoneal | Temperature | | Concentration | 6-175 mg/kg | Notes | Air extracts containing PCBs, PCDFs, PCDDs |
|
|
Described effects | | suspected endocrine effect Increased hepatic P450 enzyme activities | | Effect on thyroid hormone: 12 mg/kg: increased serum total T4 | | Effect on thyroid hormone: 38-175 mg/kg: decreased serum total T4 |
|
Literature references | Li, M.H., Hansen, L.G.(1996). Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures.Environ. Health Perspect., 104: 712-722 |
|
|