ED North Database | 2,2',4,4',5-Pentabromodiphenyl ether (BDE 99) |
Study details | Group | mammalian | Organism | Human | Tissue | | Age | | InVivo | In vitro | Lab | Laboratory | Flow | | Duration | Overnight | Route | | Temperature | 4°C | Concentration | Metabolites: max 250 nM | Notes | Metabolization by incubation with rat hepatic microsomes prior to use; max concentration with 100% conversion; T4-transthyretin competition binding study |
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Described effects | | suspected no endocrine effect No significant displacement of T4 from transthyretin | | suspected no endocrine effect Parent PBDE: no binding to transthyretin |
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Literature references | Meerts, I.L.T.M., van Zanden, J.J., Luijks, E.A.C., van Leeuwen-Bol, I., Marsh, G., Jakobsson, E., Bergman, A., Brouwer, A.(2000). Potent competitive interactions of some brominated flame retartands and related compounds with human transthyretin in vitro.Toxicol. Sci., 56: 95-104 |
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