ED North Database | Methoxychlor |
Study details | Group | amphibian | Organism | Xenopus laevis (African clawed frog) | Tissue | Ovary | Age | Adult | InVivo | In vitro | Lab | Laboratory | Flow | | Duration | 24 hours | Route | | Temperature | 20-23°C | Concentration | IC50 = 72 nM | Notes | Germinal vesicle breakdown assay |
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Described effects | | Effect on progestogen: Inhibition of progesterone-induced oocyte maturation |
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Literature references | Pickford, D.B., Morris, I.D.(1999). Effects of endocrine-disrupting contaminants on amphibian oogenesis: Methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocyte in vitro.Environ. Health Perspect., 107: 285-292 |
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