ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Octylphenol
Study details
Groupmammalian
OrganismHuman
Tissue293 embryonal kidney cells
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature
Concentration1000 nM
NotesCells transfected with human ERalpha or ERbeta expression plasmid
Described effects
Effect on estrogen: RTA for ERalpha compared to radiolabeled 17-beta-estradiol (%): 61
Effect on estrogen: RTA for ERbeta compared to radiolabeled 17-beta-estradiol (%): 57
Literature references
Kuiper, G.G.J.M., Lemmen, J.G., Carlsson, B., Corton, J.C., Safe, S.H., van der Saag, P.T., van der Burg, B., Gustafsson, J.A.(1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.Endocrinology, 139: 4252-4263
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.