ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Octylphenol
Study details
Groupmammalian
OrganismHuman
TissueUterus
Age
InVivoIn vitro
LabLaboratory
Flow
Duration24 hours
Route
Temperature5C
Concentration10 M
Notes
Described effects
Effect on retinoid hormone: 38% inhibition of tritiated All trans retinoic acid binding to RAR
suspected no endocrine effect
Very weak inhibition of tritiated 17-beta-estradiol binding to ER (< 10%)
suspected no endocrine effect
Very weak inhibition of tritiated ORG2058 binding to PR (< 10%)
Literature references
Paganetto, G., Campi, F., Varani, K., Piffanelli, A., Giovannini, G., Borea, P.A.(2000). Endocrine-disrupting agents on healthy human tissues.Pharmacol. Toxicol., 86: 24-29
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.