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Endocrine Disruption in the Scheldt estuary:
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ED North Database
Lindane (gamma-Hexachlorocyclohexane)
Physicochemical properties
Chemical name NLLindaan (gamma-Hexachloorcyclohexaan)
Chemical name ENLindane (gamma-Hexachlorocyclohexane)
CAS no58-89-9
UN-
Chemical formulaC6H6Cl6
Molecular weight290,83
Boiling point323,4C
Melting point112-113C
Density1,87 at 20C
Vapour pressure9,4E-6 mm Hg at 20C
Solubility17 mg/l at 24C
LogKow3,7
PhaseSolid
Notes
Persistenceyes
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
birdEffect on anti-estrogen
Dosing daily and thrice aweek: 18-21% egg shell thinning
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fishEffect on gonadotropin
Decreased gonadotropin levels
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fishsuspected endocrine effect
Decreased GSI
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fishEffect on steroid
Altered steroid synthesis
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fishsuspected endocrine effect
Sex dependent alteration of lipid metabolism required for ovarian recrudescence
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fishEffect on sex steroid
Decreased plasma sex steroids
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fishEffect on sex steroid
Decreased plasma and ovarian steroid levels
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fishEffect on gonadotropin releasing hormone
Impaired GnRH secretion
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fishEffect on gonadotropin
Impaired GTH secretion
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fishEffect on gonadotropin releasing hormone
Inhibition of oLH-RH action
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fishEffect on gonadotropin
Inhibition of mGTH action
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fishsuspected endocrine effect
Alteration of lipid metabolism required for ovarian recrudescence
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fishEffect on estrogen
Induction of ER and VTG mRNA
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fishEffect on thyroid hormone
Decreased plasma T3 and T4 levels
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fishEffect on thyroid hormone
Decreased T3 and increased T4 levels
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fishEffect on thyroid hormone
Decreased T3/T4 ratio
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fishEffect on estrogen
Induction of VTG mRNA expression
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mammalianEffect on gonadotropin
Increased serum LH concentrations
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mammalianEffect on gonadotropin
Non significant increased serum FSH concentrations
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mammaliansuspected endocrine effect
Non significant decrease in serum testosterone levels
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mammaliansuspected no endocrine effect
No significant inhibition of estradiol binding to ER
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mammaliansuspected no endocrine effect
No effect on [3H]5-alpha-DHT binding to ABP
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mammalianEffect on androgen
20-30% decrease in [3H]5-alpha-DHT binding to SHBG
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mammalianEffect on androgen
50% inhibition in [3H]5-alpha-DHT binding to SHBG
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mammalianEffect on androgen
IC50 = 160 M
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mammaliansuspected no endocrine effect
No effects on serum estradiol and uterine progesterone concentrations
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mammaliansuspected no endocrine effect
No effects on ER binding
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mammaliansuspected no endocrine effect
No effects on pituitary and uterus weight
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mammaliansuspected no endocrine effect
No effects on serum estradiol concentrations
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mammaliansuspected no endocrine effect
No effects on pituitary weight
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mammaliansuspected no endocrine effect
No effets on ER distribition and PR binding
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mammaliansuspected endocrine effect
Reduced ovulation rate
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mammaliansuspected endocrine effect
Reduced testicular weight
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mammaliansuspected endocrine effect
Reduced testicular weight
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mammaliansuspected endocrine effect
Degeneration of Leydig cells
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mammaliansuspected endocrine effect
Decreased serum testosterone concentrations
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mammalianEffect on anti-estrogen
Delayed vaginal opening and disrupted ovarian cycle
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mammalianEffect on anti-estrogen
Decreased serum and pituitary LH and prolactin levels
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mammaliansuspected endocrine effect
Decreased pituitary and uterus weight
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mammalianEffect on anti-estrogen
Increased pituitary FSH levels
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mammaliansuspected endocrine effect
10 mg/kg: increased serum estrogen
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mammaliansuspected endocrine effect
40 mg/kg: decreased serum estrogen
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mammalianEffect on anti-estrogen
Lower estradiol benzoate induced increase in serum LH
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mammaliansuspected endocrine effect
Decreased uterus weight
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mammalianEffect on anti-estrogen
Smaller estradiol benzoate induced decrease in pituitary LH, FSH and prolactin
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mammaliansuspected endocrine effect
Decreased testis weight
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mammaliansuspected endocrine effect
Cell abnormalities in testis
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mammalianEffect on anti-androgen
Inhibition of spermatogenesis
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mammalianEffect on anti-estrogen
Delayed vaginal opening and disrupted ovarian cycle
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mammaliansuspected endocrine effect
Reduced pituitary and uterus weight
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mammaliansuspected endocrine effect
At adulthood: reduced testicular weight
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mammalianEffect on anti-androgen
At adulthood: reduced number of sperm and spermatids
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mammalianEffect on anti-androgen
At adulthood and puberty: reduced serum testosterone levels
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mammaliansuspected endocrine effect
At adulthood: reduced testicular weight
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mammalianEffect on anti-androgen
At adulthood: reduced number of sperm and spermatids
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mammalianEffect on anti-androgen
At puberty: reduced serum testosterone levels
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mammaliansuspected endocrine effect
Reduced serum testosterone concentrations
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mammaliansuspected endocrine effect
Reduced sexual behaviour
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mammaliansuspected no endocrine effect
No effects on number of sperm and spermatids and testis weight
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mammaliansuspected no endocrine effect
No effects on reproductive function
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mammaliansuspected endocrine effect
Failure in implantation and fetotoxicity
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mammaliansuspected no endocrine effect
No effects on reproduction and maturation
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mammaliansuspected endocrine effect
Induction of MFO enzyme in liver of 3rd generation offspring
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mammaliansuspected endocrine effect
Decreased litter size
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mammaliansuspected endocrine effect
F3 males: decreased testis size
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mammalianEffect on thyroid hormone
F2 males: decreased serum T4 levels
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mammaliansuspected no endocrine effect
No effect on serum cortisol, testosterone and estradiol levels
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mammalianEffect on estrogen
Increased serum estradiol levels
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mammalianEffect on thyroid hormone
Decreased serum T4 levels
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mammalianEffect on insulin
Increased serum insulin levels
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mammalianEffect on gonadotropin
Decreased basal serum LH levels
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mammaliansuspected endocrine effect
Reduced pregnancy rate
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mammaliansuspected endocrine effect
Increased thyroid follicle size
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yeastsuspected no endocrine effect
No estrogenic activity
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yeastEffect on estrogen
Dose-dependent induction of ER-mediated gene transcription
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.