ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Hexachlorobenzene
Physicochemical properties
Chemical name NLHexachlorobenzeen
Chemical name ENHexachlorobenzene
CAS no118-74-1
UN-
Chemical formulaC6Cl6
Molecular weight284,76
Boiling point322C
Melting point229C
Density2,04 at 23C
Vapour pressure1,09E-5 mm Hg at 20 C
Solubility6 g/l
LogKow-
PhaseSolid
NotesPotent inducer of hepatic microsomal enzymes
Persistenceyes
Degradation
Accumulationyes
Endocrien effect studies
Organism group Effect 
mammaliansuspected endocrine effect
Decreased serum testosterone concentrations
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mammaliansuspected endocrine effect
Increased in vitro hepatic microsomal testosterone metabolism
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mammaliansuspected endocrine effect
Decreased serum testosterone concentrations
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mammalianEffect on reproductive hormone
Decreased fertility
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mammaliansuspected endocrine effect
Histopathology of testes leading to retarded maturation
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mammaliansuspected endocrine effect
Reduced litter size
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mammaliansuspected endocrine effect
Increased number of stillbirths
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mammalianEffect on thyroid hormone
Thyroid tumours in males
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mammalianEffect on thyroid hormone
Decreased serum T3 levels, no effect on serum T4
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mammaliansuspected endocrine effect
Increased thyroid size
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mammalianEffect on thyroid hormone
Decreased serum T4 levels, Slight decrease in serum T3 levels
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mammalianEffect on thyroid hormone
Decreased serum levels of total and free T3
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mammalianEffect on thyroid hormone
Decreased serum levels of total and free T4
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mammalianEffect on retinoid hormone
Disturbed retinoid hormone homeostasis
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mammaliansuspected no endocrine effect
No effect on fertility
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mammaliansuspected endocrine effect
F1: increased incidence of parathyroid adenomas
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mammaliansuspected endocrine effect
Possitive correlation between concentration levels and decreased female birth weights
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.