ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Nonylphenol
Physicochemical properties
Chemical name NLNonylfenol
Chemical name ENNonylphenol
CAS no25154-52-3
UN-
Chemical formulaC15H24O
Molecular weight220,39
Boiling point315C
Melting point-
Density0,95
Vapour pressure-
SolubilityPractically insoluble
LogKow4.5
PhaseLiquid
Notes
Persistenceno
Degradation
Accumulationyes
Endocrien effect studies
Organism group Effect 
fishsuspected endocrine effect
10 M: sublethal embryonal and larval developmental abnormalities
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fishsuspected endocrine effect
10 M: decreased hatching succes
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fishsuspected endocrine effect
25 M: lethal developmental abnormalities (no survival to hatching age)
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fishsuspected no endocrine effect
50-100 M: acute lethal
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fishsuspected no endocrine effect
Acute lethal
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fishEffect on estrogen
Induction of vitellogenesis
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fishEffect on estrogen
Induction of vitellogenesis
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fishEffect on estrogen
Decreased number of hatchings
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fishEffect on estrogen
Approximately 300-fold increases in plasma VTG levels
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mammalianEffect on estrogen
75% reduction of tritiated 17-beta-estradiol binding to ER
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mammaliansuspected no endocrine effect
No effect on tritiated 5-alpha-DHT binding on AR
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mammalianEffect on androgen
70% decrease in tritiated 5-alpha-DHT binding to SHBG
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mammalianEffect on estrogen
Induction of hER-mediated transcription
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mammalianEffect on estrogen
20% inhibition of tritiated 17-beta-estradiol binding to ER
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mammalianEffect on estrogen
Dose-dependent induction of ER-mediated activity
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mammalianEffect on estrogen
Dose-dependent uterotrophic activity
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mammalianEffect on estrogen
Dose-dependent induction of ERalpha-mediated gene expression
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mammalianEffect on estrogen
Dose-dependent induction of ERalpha- and ERbeta-mediated gene expression
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molluscEffect on androgen
Development of imposex
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yeastEffect on estrogen
Induction of hER-mediated transcription
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.