ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
PCB
Physicochemical properties
Chemical name NLPCB
Chemical name ENPCB
CAS no1336-36-3
UN-
Chemical formulaC12HxCly
Molecular weight291,99
Boiling point-
Melting point-
Density-
Vapour pressure-
Solubility-
LogKow-
PhaseLiquid
Notes
Persistenceyes
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
amphibiansuspected endocrine effect
Sex reversal female to male
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birdsuspected endocrine effect
Increased nest abandonment and reduced hatching
Show study
fishEffect on estrogen
Increased plasma VTG levels compared to control site
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fishEffect on estrogen
Occurrence of ovotestis and intersex
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fishsuspected endocrine effect
Increased hepatic EROD activity
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mammalianEffect on retinoid hormone
NOEC for retinol reduction: 2 ng TEQ/g lipid
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mammalianEffect on retinoid hormone
EC90 for retinol reduction: 5 ng TEQ/g lipid
Show study
mammalianEffect on thyroid hormone
Increased total and free plasma T4
Show study
mammaliansuspected endocrine effect
Abnormal sperm and low sperm density
Show study
mammaliansuspected endocrine effect
Cryptorchidism
Show study
mammaliansuspected endocrine effect
No significant difference between serum estradiol levels in males and females
Show study
mammaliansuspected endocrine effect
Increased hepatic P450 enzyme activities
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mammalianEffect on thyroid hormone
32-346 mg/kg: decreased serum total T4
Show study
mammaliansuspected endocrine effect
Increased hepatic P450 enzyme activities
Show study
mammalianEffect on thyroid hormone
38-382 mg/kg: decreased serum total T4
Show study
mammaliansuspected endocrine effect
Increased hepatic P450 enzyme activities
Show study
mammalianEffect on thyroid hormone
12 mg/kg: increased serum total T4
Show study
mammalianEffect on thyroid hormone
38-175 mg/kg: decreased serum total T4
Show study
mammaliansuspected no endocrine effect
No apparent association between serum concentrations and the risk of breast cancer
Show study
reptilesuspected endocrine effect
Reduction in PPR
Show study
reptilesuspected endocrine effect
Overlapping of PPRs of males with those of females
Show study
Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.