ENDIS-RISKS
Endocrine Disruption in the Scheldt estuary:
distribution, exposure and effects
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ED North Database
Octylphenol
Physicochemical properties
Chemical name NLOctylfenol
Chemical name ENOctylphenol
CAS no27193-28-8
UN-
Chemical formulaC14H22O
Molecular weight206.36
Boiling point-
Melting point-
Density-
Vapour pressure-
Solubility-
LogKow-
Phase-
Notes
Persistence
Degradation
Accumulation
Endocrien effect studies
Organism group Effect 
amphibiansuspected no endocrine effect
No inhibition of progesterone-induced oocyte maturation
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fishEffect on estrogen
Upregulation of hepatic ER
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fishEffect on estrogen
Induction of zonaradiata proteins
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fishEffect on estrogen
Additivity in combination with butylbenzylphtalate or 17-beta-estradiol
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mammalianEffect on estrogen
RBA compared to radiolabeled 17-beta-estradiol (%): 0.02
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mammalianEffect on estrogen
RBA compared to radiolabeled 17-beta-estradiol (%): 0.07
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mammaliansuspected endocrine effect
Reduction in efferent duct epithelial cell height
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mammalianEffect on retinoid hormone
38% inhibition of tritiated All trans retinoic acid binding to RAR
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mammaliansuspected no endocrine effect
Very weak inhibition of tritiated 17-beta-estradiol binding to ER (< 10%)
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mammaliansuspected no endocrine effect
Very weak inhibition of tritiated ORG2058 binding to PR (< 10%)
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mammalianEffect on retinoid hormone
16% inhibition of tritiated All trans retinoic acid binding to RAR
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mammalianEffect on androgen
15% inhibition of tritiated R1881 binding to AR
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mammalianEffect on estrogen
RTA for ERalpha compared to radiolabeled 17-beta-estradiol (%): 61
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mammalianEffect on estrogen
RTA for ERbeta compared to radiolabeled 17-beta-estradiol (%): 57
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Data compiled by the Research Group Environmental Toxicology, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Belgium.
For queries about the data, please contact Colin Janssen or Tim Verslycke .
More info about the contents and the structure of the database can be found on the about screen.