ED North Database | Cadmium |
Study details | Group | mammalian | Organism | Sprague-Dawley rat, male | Tissue | | Age | Pubertal (30 days) | InVivo | In vivo | Lab | Laboratory | Flow | | Duration | 30 days | Route | Subcutaneous | Temperature | 22°C | Concentration | 0.5 or 1 mg/kg body weight | Notes | Dosing from days 30 to 60 every 4 days in an alternate schedule |
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Described effects | | Effect on neurohormone: Decreased 5-HT levels in hypothalamus | | Effect on neurohormone: Increased 5-HT turnover in anterior hypothalamus and median eminence | | Effect on androgen: Increased plasma testosterone levels | | suspected endocrine effect Age dependent accumulation of Cd in hypothalamus and testes | | Effect on catecholamine: Increased NE levels in hypothalamus | | Effect on catecholamine: Decreased NE levels in median eminence |
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Literature references | Lafuente, A., Marquez, N., Pérez-Lorenzo, M., Pazo, D., Esquifino, A.I.(2000). Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat.Food Chem. Toxicol., 38: 913-923 |
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