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The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae
Natrah, F.M.I.; Alam, M.I.; Pawar, S.; Harzevili, A.S.; Nevejan, N.; Boon, N.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2012). The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae. Vet. Microbiol. 159(1-2): 77-82. https://dx.doi.org/10.1016/j.vetmic.2012.03.014
In: Veterinary Microbiology. Elsevier: Tokyo; Oxford; New York; London; Amsterdam. ISSN 0378-1135; e-ISSN 1873-2542
Peer reviewed article  
Available in  Authors 
Keyword
    Aeromonas Stanier, 1943 [WoRMS]
Author keywords
    Quorum sensing; Aeromonas sp.; Acylated homoserine lactone; Quorumsensing inhibitor; Cinnamaldehyde; Micro-alga
Authors  Top 
  • Natrah, F.M.I.
  • Alam, M.I.
  • Pawar, S.
  • Harzevili, A.S.
  • Nevejan, N.
  • Boon, N.
  • Sorgeloos, P., more
  • Bossier, P., more
  • Defoirdt, T.
Abstract
    In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-l-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-l-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.
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