| Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, antifungal, antiinflammatory, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action |  |
| Mayer, A.M.S.; Lehmann, V.K.B. (2000). Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, antifungal, antiinflammatory, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action The Pharmacologist 42(2): 62-69 |
| In: The Pharmacologist. American Society for Pharmacology and Experimental Therapeutics: Bethesda. ISSN 0031-7004, meer |
| Abstract |
During 1998 research on the pharmacology of marine chemicals included in this review involved investigators from 22 countries, namely Australia, Belgium, Bolivia, Brazil, Canada, China, France, Germany, India, Italy, Japan, the Netherlands, Norway, New Zealand, Philippines, Russia, Slovenia, Spain, Switzerland, United Kingdom, Uruguay and the United States. This review attempts to classify 59 peer-reviewed articles on the basis of the reported preclinical pharmacological properties of marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. Thirty marine chemicals had antibacterial, anticoagulant, antifungal, antihelminthic, antiplatelet, antiprotozoal or antiviral activities. An additional seventeen marine compounds were shown to have significant effects on the cardiovascular, immune or nervous system. Finally, twenty marine compounds were reported to act on a variety of molecular targets that could potentially contribute to various pharmacological classes. Thus, during 1998, marine organisms provided a variety of novel chemical leads for the potential development of new therapeutic agents for the treatment of multiple disease categories. |
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