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Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels
Bosmans, F.; Tytgat, J. (2007). Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. Toxicon 49(4): 550-560. dx.doi.org/10.1016/j.toxicon.2006.11.029
In: Toxicon. Elsevier: Oxford. ISSN 0041-0101; e-ISSN 1879-3150
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Aquatic organisms > Marine organisms > Aquatic animals > Marine invertebrates
    Biological phenomena > Evolution
    Biology > Physiology > Animal physiology
    Cells > Receptors
    Chemical compounds > Organic compounds > Proteins > Peptides
    Fauna > Aquatic organisms > Aquatic animals > Aquatic insects
    Materials > Hazardous materials > Biological poisons
    Materials > Hazardous materials > Biological poisons > Neurotoxins
    Pesticides > Insecticides
    Toxins
    Actiniaria [WoRMS]
    Marien/Kust
Author keywords
    sea anemone; voltage-gated sodium channel; insecticide; toxin; site 3;ATX-II
Auteurs  Top 
  • Bosmans, F.
  • Tytgat, J., meer
Abstract
    Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
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