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Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand
Kijjoa, A.; Wattanadilok, R.; Campos, N.; Nascimento, M.S.J.; Pinto, M.; Herz, W. (2007). Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand. Mar. Drugs 5(2): 6-22
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

Available in  Authors 

Keywords
    Apoptosis; Apoptosis; Oceanapia Norman, 1869 [WoRMS]; Marine

Authors  Top 
  • Kijjoa, A.
  • Wattanadilok, R.
  • Campos, N.
  • Nascimento, M.S.J.
  • Pinto, M.
  • Herz, W.

Abstract
    The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24a-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells.

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