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Monoindole alkaloids from a marine sponge Spongosorites sp.
Bao, Q.; Zhang, P.; Lee, Y.; Hong, J.; Lee, C.-O.; Jung, J.H. (2007). Monoindole alkaloids from a marine sponge Spongosorites sp. Mar. Drugs 5(2): 31-39
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

Available in Authors 

Keywords
    Alkaloids; Cytotoxicity; Porifera [WoRMS]; Marine

Authors  Top 
  • Bao, Q.
  • Zhang, P.
  • Lee, Y.
  • Hong, J.
  • Lee, C.-O.
  • Jung, J.H.

Abstract
    Seven (1-7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1-5 are unique indole pyruvic acid derivatives. Compounds 1-2 and 4-6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.

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