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Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge Pachychalina sp.
De Oliveira, J.H.H.L.; Seleghim, M.H.R.; Timm, C.; Grube, A.; Köck, M.; Nascimento, G.G.F.; Martins, A.C.T.; Silva, E.G.O.; De Souza, A.O.; Minarini, P.R.R.; Galetti, F.C.S.; Silva, C.L.; Hajdu, E.; Berlinck, R.G.S. (2006). Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge Pachychalina sp. Mar. Drugs 4(1): 1-8
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397, more
Peer reviewed article  

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Keywords
    Alkaloids; Antibacterials; Antibiotics; Pseudomonas aeruginosa; Pseudomonas aeruginosa; Candida albicans; Escherichia coli Castellani & Chalmers, 1919 [WoRMS]; Mycobacterium tuberculosis; Porifera [WoRMS]; Pseudomonas aeruginosa; Staphylococcus aureus; Marine

Authors  Top 
  • De Oliveira, J.H.H.L.
  • Seleghim, M.H.R.
  • Timm, C.
  • Grube, A.
  • Köck, M.
  • Nascimento, G.G.F.
  • Martins, A.C.T.
  • Silva, E.G.O.
  • De Souza, A.O.
  • Minarini, P.R.R.
  • Galetti, F.C.S.
  • Silva, C.L.
  • Hajdu, E.
  • Berlinck, R.G.S.

Abstract
    Cyclostellettamines A - F (1 - 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 - 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines.

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