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Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2006). Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett. 580(24): 5728-5732.
In: FEBS Letters. ELSEVIER SCIENCE BV: Amsterdam. ISSN 0014-5793, more
Peer reviewed article  

Available in  Authors 
    VLIZ: Open Repository 133931 [ OMA ]

    Biological poisons; Desensitization; Envenomation; Marine invertebrates; Neurons; Noxious organisms; Public health; Venoms; Cnidaria [WoRMS]; Marine
Author keywords
    cnidaria; TRPV1; envenomation; pain; desensitization

Authors  Top 
  • Cuypers, E., more
  • Yanagihara, A.
  • Karlsson, E.
  • Tytgat, J., more

    Cnidarian envenomations cause a burning-pain sensation of which the underlying mechanisms are unknown. Activation of TRPV1, a non-selective cation channel expressed in nociceptive neurons, leads to cell depolarisation and pain. Here, we show in vitro and in vivo evidence for desensitization-dependent TRPV1 activation in cnidarian envenomations. Cnidarian venom induced a nociceptive reactivity, comparable to capsaicin, in laboratory rats, which could be reduced by the selective TRPV1 antagonist, BCTC. These findings are the first to explain at least part of the symptomology of cnidarian envenomations and provide insights into the design of more effective treatments for this global public health problem. (

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