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Eicosanoids from the tropical red alga Murrayella periclados
Bernart, M.W.; Gerwick, W.H. (1994). Eicosanoids from the tropical red alga Murrayella periclados. Phytochemistry 36(5): 1233-1240
In: Phytochemistry. PERGAMON-ELSEVIER SCIENCE LTD: Oxford. ISSN 0031-9422, more
Peer reviewed article  

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    Aquatic drugs; Chemical composition; Fatty acids; Metabolites; Pharmacology; Seaweeds; Murrayella periclados (C.Agardh) F.Schmitz, 1893 [WoRMS]; Rhodomelaceae J.E. Areschoug, 1847 [WoRMS]; Marine

Authors  Top 
  • Bernart, M.W.
  • Gerwick, W.H.

    Lipid extracts of several collections of the tropical red marine alga Murrayella periclados were found to be rich sources of eicosanoids more commonly associated with mammalian systems, including 12S-hydroxyeicosapentaenoic acid, 12S-hydroxyeicosatetraenoic acid, (6E)-leukotriene B4, and erythro and threo diastereomers of hepoxilins B3 and B4. This is the first report of leukotriene or hepoxilin B sub(4) natural products from a plant, and several spectroscopic features of these molecules are reported herein for the first time. Two conjugated triene-containing acids recently reported from another red alga, 5Z,7E,9E,14Z,17Z-eicosapentaenoic acid and 5E,7E,9E,14Z,17Z-eicosapentaenoic acid, were also found in the algal extract. A 12-lipoxygenase initiated biosynthetic origin is proposed for most of these Murrayella oxylipins.

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