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Crude oil impairs cardiac excitation-contraction coupling in fish
Brette, F.; Machado, B.; Cros, C.; Incardona, J.P.; Scholz, N.L.; Block, B.A. (2014). Crude oil impairs cardiac excitation-contraction coupling in fish. Science (Wash.) 343(6172): 772-776. hdl.handle.net/10.1126/science.1242747
In: Science (Washington). American Association for the Advancement of Science: New York, N.Y. ISSN 0036-8075, more
Peer reviewed article  

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Keyword
    Marine

Authors  Top 
  • Brette, F.
  • Machado, B.
  • Cros, C.
  • Incardona, J.P.
  • Scholz, N.L.
  • Block, B.A.

Abstract
    Crude oil is known to disrupt cardiac function in fish embryos. Large oil spills, such as the Deepwater Horizon (DWH) disaster that occurred in 2010 in the Gulf of Mexico, could severely affect fish at impacted spawning sites. The physiological mechanisms underlying such potential cardiotoxic effects remain unclear. Here, we show that crude oil samples collected from the DWH spill prolonged the action potential of isolated cardiomyocytes from juvenile bluefin and yellowfin tunas, through the blocking of the delayed rectifier potassium current (IKr). Crude oil exposure also decreased calcium current (ICa) and calcium cycling, which disrupted excitation-contraction coupling in cardiomyocytes. Our findings demonstrate a cardiotoxic mechanism by which crude oil affects the regulation of cellular excitability, with implications for life-threatening arrhythmias in vertebrates.

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