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Germ-free sea bass Dicentrarchus labrax larval model: a valuable tool in the study of host-microbe interactions
Schaeck, M.; De Swaef, E.; Van Den Broeck, W.; Van Nevel, S.; Boon, N.; De Geyter, N.; Morent, R.; Demeestere, K.; Duchateau, L.; Coulombet, C.; Haesebrouck, F.; Decostere, A. (2016). Germ-free sea bass Dicentrarchus labrax larval model: a valuable tool in the study of host-microbe interactions. Dis. Aquat. Org. 117(3): 177-185. dx.doi.org/10.3354/dao02950
In: Diseases of Aquatic Organisms. Inter Research: Oldendorf/Luhe. ISSN 0177-5103, more
Peer reviewed article  

Available in  Authors 
    VLIZ: Open access 294822 [ available from 01/01/2021 on ]

Keyword
    Marine
Author keywords
    Aquaculture; Gnotobiotic; Pathogen; Larvae

Authors  Top 
  • Schaeck, M., more
  • De Swaef, E., more
  • Van Den Broeck, W., more
  • Van Nevel, S., more
  • Boon, N., more
  • De Geyter, N.
  • Morent, R.
  • Demeestere, K., more
  • Duchateau, L., more
  • Coulombet, C.
  • Haesebrouck, F., more
  • Decostere, A., more

Abstract
    A thorough understanding of host-microbe interactions is crucial for more efficient disease management in the marine larviculture industry. As demonstrated in terrestrial animal research, gnotobiotic systems (involving animals cultured in germ-free conditions or inoculated with known microorganisms) are excellent tools to extend our understanding of the mechanisms involved in host-microbe interactions and allow the evaluation of new treatments for diseases. In this study, we introduce a germ-free European sea bass Dicentrarchus labrax larval model, independent of the continuous addition of antimicrobial agents. This model has an experimental set-up that allows addition of live feed to the larvae without compromising the germ-free status. This model will facilitate and render aquaculture research more effective in terms of mitigation fish larval diseases.

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