| Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex König |  |
| Regalado, E.L.; Rodríguez, M.; Menéndez, R.; Concepción, Á.A.; Nogueiras, C.; Laguna, A.; Rodríguez, A.A.; Williams, D.E.; Lorenzo-Luaces, P.; Valdés, O.; Hernandez, Y. (2009). Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex König Mar. Biotechnol. 11(1): 74-80. dx.doi.org/10.1007/s10126-008-9123-8 |
| In: Marine Biotechnology. Springer-Verlag: New York. ISSN 1436-2228, meer |
| Trefwoorden |
Thalassia testudinum [WoRMS]; Marien |
| Auteurs | | Top |
- Regalado, E.L., publicatielijst
- Rodríguez, M., publicatielijst
- Menéndez, R., publicatielijst
- Concepción, Á.A., publicatielijst
- Nogueiras, C., publicatielijst
- Laguna, A., publicatielijst
|
- Rodríguez, A.A., publicatielijst
- Williams, D.E., publicatielijst
- Lorenzo-Luaces, P., publicatielijst
- Valdés, O., publicatielijst
- Hernandez, Y., publicatielijst
|
| Abstract |
Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 µg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 µg/cm2) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC50=100 ?g/ml. These results suggest that thalassiolin B is responsible for the skin-regenerating effects of the crude extract of T. testudinum. |
|
