Manzamenones inhibit T-cell protein tyrosine phosphatase
Wakuda, Y.; Kubota, T.; Shima, H.; Okada, T.; Mitsuhashi, S.; Aoki, N.; Kikuchi, K.; Kobayashi, J. (2006). Manzamenones inhibit T-cell protein tyrosine phosphatase. Mar. Drugs 4(1): 9-14. https://dx.doi.org/10.3390/md401009
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
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Keywords |
Agents > Inhibitors Plakortis Schulze, 1880 [WoRMS] Marine/Coastal |
Authors | | Top |
- Wakuda, Y.
- Kubota, T.
- Shima, H.
- Okada, T.
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- Mitsuhashi, S.
- Aoki, N.
- Kikuchi, K.
- Kobayashi, J.
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Abstract |
Manzamenones A-C (1-3) and E-F (5-6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B). |
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