Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe
Bondu, S.; Genta-Jouve, G.; Leir?s, M.; Vale, C.; Guigonis, J.-M.; Botana, L.M.; Thomas, O.P. (2012). Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe. Rsc Advances 2(7): 2828-2835. https://dx.doi.org/10.1039/c2ra00045h
In: RSC Advances. Royal Society of Chemistry: Cambridge. e-ISSN 2046-2069, more
|  |
| Keywords |
Crambe crambe (Schmidt, 1862) [WoRMS]
Marine/Coastal |
| Authors | | Top | Dataset |
- Bondu, S.
- Genta-Jouve, G.
- Leir?s, M.
- Vale, C.
|
- Guigonis, J.-M.
- Botana, L.M.
- Thomas, O.P.
|
|
| Abstract |
The full chemical reinvestigation of the Mediterranean marine sponge Crambe crambe led to the isolation and structural characterization of 11 crambescin derivatives, including 8 new compounds, together with the known crambescidin 816. HRMS/MS studies allowed the complete assignment of the alkyl chain lengths of these guanidine alkaloids while the absolute configurations of all compounds were inferred from the comparison between experimental and theoretical circular dichroism spectra. Crambescidin 816 was proven to be more cytotoxic against neuronal cell lines than crambescin C1. |
| Dataset |
- CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019., more
|
|
