IMIS | Flanders Marine Institute
 

Flanders Marine Institute

Platform for marine research

IMIS

Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Print this page

Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway
Asselman, J.; Van Acker, E.; De Rijcke, M.; Tilleman, L.; Van Nieuwerburgh, F.; Mees, J.; De Schamphelaere, K.; Janssen, C. (2019). Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. NPG Scientific Reports 9(1): 10 pp. https://hdl.handle.net/10.1038/s41598-018-36866-3
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, more
Peer reviewed article  

Available in  Authors 

Authors  Top 
  • Asselman, J., more
  • Van Acker, E., more
  • De Rijcke, M., more
  • Tilleman, L.
  • Van Nieuwerburgh, F.
  • Mees, J., more
  • De Schamphelaere, K., more
  • Janssen, C., more

Abstract
    Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors