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Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds
Schepers, M.; Martens, N.; Tiane, A.; Vanbrabant, K.; Liu, H.-B.; Lütjohann, D.; Mulder, M.; Vanmierlo, T. (2020). Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds. Neural Regeneration Research 15(5): 790-795. https://dx.doi.org/10.4103/1673-5374.268894
In: Neural Regeneration Research: Mumbai. ISSN 1673-5374; e-ISSN 1876-7958, more
Peer reviewed article  

Available in  Authors 

Keywords
    Algae
    Marine/Coastal
Author keywords
    algae; carotenoids; neuro-active; phenols; phytosterols; polysaccharides; seaweed

Authors  Top 
  • Schepers, M., more
  • Martens, N.
  • Tiane, A., more
  • Vanbrabant, K., more
  • Liu, H.-B.
  • Lütjohann, D.
  • Mulder, M.
  • Vanmierlo, T., more

Abstract
    Edible marine algae, or seaweeds, are a rich source of several bioactive compounds including phytosterols, carotenoids, and polysaccharides. Over the last decades, seaweed-derived constituents turned out to not only reside in the systemic circulation, but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions. Therefore, seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties, rendering them interesting candidates for the management of several neurodegenerative disorders. In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity, enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties. Though, the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids, phenols and polysaccharides have recently gained more interest. In this review, we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

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