Five species of Anisomysis were collected from a coral reef flat on Grande Comore, Western Indian Ocean. Anisomysis hanseni Nouvel, 1967, A. marisrubri Bacescu, 1973a and A. vasseuri Ledoyer, 1974 represent new distribution records for the three species. Two new species are described. Anisomysis unispinosa sp. nov. is distinguished by the presence of a single spine at the distal end of the telsonic lobes of the deeply cleft telson. Anisomysis comorensis sp. nov. is distinguished by the truncate distal border of the telson and its armature.