IMIS | Flanders Marine Institute

Flanders Marine Institute

Platform for marine research


Publications | Institutes | Persons | Datasets | Projects | Maps
[ report an error in this record ]basket (0): add | show Print this page

Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods
Nishikawa, J.-I.; Mamiya, S.; Kanayama, T.; Nishikawa, T.; Shiraishi, F.; Horiguchi, T. (2004). Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. Environ. Sci. Technol. 38(23): 6271-6276.
In: Environmental Science and Technology. American Chemical Society: Easton. ISSN 0013-936X; e-ISSN 1520-5851, more
Peer reviewed article  

Available in  Authors 

    Organotin compounds
    Gastropoda [WoRMS]

Authors  Top 
  • Nishikawa, J.-I.
  • Mamiya, S.
  • Kanayama, T.
  • Nishikawa, T.
  • Shiraishi, F.
  • Horiguchi, T.

    Organotin compounds released from antifouling paints, such as tributyltin (TBT) and triphenyltin (TPT), are potent inducers of imposex (a superimposition of male genital tracts, such as penis and vas deferens, on females) in marine gastropods. Little is known about the induction mechanism of gastropod imposex. Here, we show that organotins bind the human retinoid X receptors (hRXRs) with high affinity and that injection of 9-cis retinoic acid (RA), the natural ligand of hRXRs, into females of the rock shell (Thais clavigera) induces the development of imposex. Cloning of the RXR homologue from T. clavigera revealed that the ligand-binding domain of rock shell RXR was very similar to vertebrate RXR and bound to both 9-cis RA and to organotins. These suggest that RXR plays an important role in inducing the development of imposex, namely, the differentiation and growth of male genital tracts in female gastropods.

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors