Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
Bugni, T.S.; Richards, B.; Bhoite, L.; Cimbora, D.; Harper, M.K.; Ireland, C.M. (2008). Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery. J. Nat. Prod. 71(6): 1095-1098
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
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| Auteurs | | Top |
- Bugni, T.S.
- Richards, B.
- Bhoite, L.
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- Cimbora, D.
- Harper, M.K.
- Ireland, C.M.
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| Abstract |
There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells. |
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