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Total synthesis of μ-conotoxin lt5d
Naraga, A.M.B.; Belleza, O.J.V.; Villaraza, A.J.L. (2018). Total synthesis of μ-conotoxin lt5d. Rsc Advances 8(64): 36579-36583. https://dx.doi.org/10.1039/c8ra03706j
In: RSC Advances. Royal Society of Chemistry: Cambridge. e-ISSN 2046-2069, meer
Peer reviewed article  
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  • Naraga, A.M.B.
  • Belleza, O.J.V.
  • Villaraza, A.J.L.
Abstract
    The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.
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