A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera
Ouahabi, S.; Daoudi, N.E.; Chebaibi, M.; Mssillou, I.; Rahhou, I.; Bnouham, M.; HAMMOUTI, B.; Fauconnier, M.; GOTOR, A.A.; Rhazi, L.; Ramdani, M. (2025). A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera. Mar. Drugs 23(7): 259. https://dx.doi.org/10.3390/md23070259
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, meer
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| Author keywords |
Caulerpa prolifera;fatty acids;phenolic compounds;antioxidant activity;anti-diabetic properties;enzyme inhibition;alpha-glucosidase;sulfated polysaccharides;natural-products;atlantic coasts;green-algae;racemosa;seaweeds;amylase;chlorophyceae;flavonoids |
| Auteurs | | Top |
- Ouahabi, S.
- Daoudi, N.E.
- Chebaibi, M.
- Mssillou, I.
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- Rahhou, I.
- Bnouham, M.
- HAMMOUTI, B.
- Fauconnier, M., meer
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- GOTOR, A.A.
- Rhazi, L.
- Ramdani, M.
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| Abstract |
The Moroccan coastline has been the focus of attention for researchers studying the national algal flora, with the aim of preserving these invaluable natural resources. Since the year 2000, these resources have stimulated great interest in the creation of new drugs, as well as their integration into food supplements and foods. Therefore, this study aims to explore the phytochemistry of a series of extracts derived from Caulerpa prolifera. To ensure better extraction of the various metabolites present, two extraction methods, namely maceration and the Soxhlet method, were employed using solvents of varying polarity (hexane, ethyl acetate, methanol, and water). The chemical composition of the extracts was analyzed using GC-MS for fatty acids and HPLC-DAD for phenolic compounds. Antioxidant activity was evaluated using DPPH and beta-carotene bleaching assays, while antidiabetic potential was assessed by in vitro inhibition of alpha-amylase and alpha-glucosidase. In addition, Molecular docking models were employed to assess the interaction between the bioactive molecules and the human pancreatic alpha-amylase and alpha-glucosidase enzymes. Vanillin, p-coumaric acid, sinapic acid, 7,3 ',4 '-flavon-3-ol, and kaempferol were the most abundant phenolic compounds. Anti-diabetic and antioxidant effects were highly significant. |
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